Effect of"Tongdu Xingshen"Acupuncture Combination Treatment on Post-stroke Mild Cognitive Impairment and Its Impact on Serum BDNF and NSE Levels
HUANG Shan
ZHANG Menghong
LIU Xin
WANG Xiaowei
LI Guozheng
LIU Jing
Abstract：Objective To observe the effect of"Tongdu Xingshen"acupuncture combination treatment on post-stroke mild cognitive impairment(PSMCI)and its impact on serum brain-derived neurotrophic factor(BDNF)and neuron-specific enolase(NSE).Methods A total of 124 patients with PSMCI treated from January 2020 to January 2024 were divided into two groups by random number table method.The control group was given conventional treatment combined with cognitive training,and the observation group was treated with"Tongdu Xingshen"acupuncture therapy for 4 weeks.The clinical effect and adverse reactions of the two groups were compared after treatment,as well as the score of Mini-Mental State Examination(MMSE),Montreal Cognitive Assessment Scale(MoCA),modified Barthel Index Rating Scale(MBI)and BDNF and NSE levels before and after treatment.Results The total effective rate of observation group was 91.94%(57/62),which was higher than that of control group[77.42%(48/62)],showing significant difference(P<0.05).After treatment,the scores of MMSE,MoCA and MBI were increased in the two groups,and the above scores were higher in observation group(P<0.05,P<0.01).After treatment,the level of BDNF was increased in both groups,which was higher in the observation group than in the control group(P<0.05,P<0.01).After treatment,the level of NSE was decreased in both groups,which was lower in the observation group than in the control group(P<0.05,P<0.01).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion"Tongdu Xingshen"acupuncture combination treatment is more effective in the treatment of PSMCI patients,which can effectively reduce cognitive impairment,improve cognitive function and self-care ability,protect nerve cells,and has high safety
Keywords：StrokeMild cognitive impairmentAcupunctureBrain-derived neurotrophic factorNeuron specific enolaseMontreal cognitive assessment scale
Publication Date：2025-06-13
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 97-100 )