Impact of Oxycodone and Sufentanil Anesthesia Induction on the Recovery Time after TURP and Catheter-related Bladder Irritation Signs

YE Hui; HU Shenghong; WANG Shengbin; WANG Xing; JU Xia; WANG Weibing

doi:10.3969/j.issn.1002-3429.2025.11.017

Abstract：Objective To analyze and compare the effects of Oxycodone and Sufentanil anesthesia induction on the postoperative recovery time and catheter-related bladder discomfort(CRBD)in patients undergoing transurethral resection of the prostate(TURP).Methods Eighty patients who underwent TURP from January 2022 to October 2024 were selected as the research subjects.They were divided into an observation group(n=40)and a control group(n=40)using the random number table method.The observation group was given Oxycodone at a dose of 0.15 mg/kg during anesthesia induction,and the control group was given Sufentanil at a dose of 0.5 μg/kg during anesthesia induction.Other anesthetic drugs and methods were identical in both groups.The heart rate(HR)and mean arterial pressure(MAP)were monitored at the time of admission to the operating room(T0),immediately after laryngeal mask insertion(T1),at 5 min after laryngeal mask placement(T2),at the initiation of the operation(T3),and immediately after laryngeal mask removal(T4)in both groups.The duration of operation,duration of anesthesia,total Remifentanil dosage,recovery time of spontaneous breathing,recovery time,Visual Analogue Scale(VAS)scores at 10 min,1 h,and 2 h after waking up,Ramsay sedation scores,the incidence of CRBD within 4 h after surgery,and the occurrence of postoperative adverse reactions were compared between the two groups.Results There were no significant differences in the duration of operation time,duration of anesthesia,total Remifentanil dosage,recovery time of spontaneous breathing,and recovery time between the two groups(P>0.05).The MAP and HR levels at T1 and T4 in both groups were higher than those at T0,which,however,were lower in the observation group than in the control group(P<0.05).With the passage of time,the VAS scores and Ramsay sedation scores after waking up in both groups increased(P<0.05);the VAS scores at 10 min,1 h,and 2 h after waking up in the observation group were lower than those in the control group,and the Ramsay sedation scores at 1 h and 2 h after waking up were higher than those in the control group(P<0.05).The incidence of CRBD within 4 h after surgery in the observation group was 20.00%(8/40),which was lower than 42.50%(17/40)in the control group,and the difference was significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Compared with Sufentanil,the application of Oxycodone for anesthesia induction during TURP can better maintain the hemodynamic stability of patients,has better analgesic and sedative effects,can reduce the occurrence of CRBD,does not increase adverse reactions,and has no obvious effect on the postoperative recovery time.