Observation on the Effect of Bilateral Thoracic Paravertebral Ganglion Block Combined with General Anesthesia in Patients Undergoing Laparoscopic Pancreaticoduodenectomy

GUO Zongwen; PENG Xiaojing; WU Limei

doi:10.3969/j.issn.1002-3429.2025.11.015

Abstract：Objective To observe the effect of bilateral thoracic paravertebral ganglion block(TPVB)combined with general anesthesia in patients undergoing laparoscopic pancreaticoduodenectomy(PD).Methods A total of 102 patients undergoing laparoscopic PD from January 2022 to June 2023 were selected and divided into an observation group(n=51)and a control group(n=51)by the random number table method.The control group was given simple general anesthesia,while the observation group received bilateral TPVB before induction of general anesthesia during surgery.The two groups were compared at different time points[before anesthesia induction(T0),at 5 min after general anesthesia induction(T1),at the time of skin incision(T2),and at 30 min after the initiation of surgery(T3)and at the end of the surgery(T4)in terms of hemodynamic indicators[heart rate(HR)and mean arterial pressure(MAP)],surgical indicators,intraoperative Sufentanil dosage,patient-controlled intravenous analgesia(PCIA)during operation,postoperative recovery indicators,and the occurrence of perioperative adverse reactions.Results The HR and MAP in the observation group at T2,T3 and T4 were significantly lower than those in the control group(P<0.05,P<0.01).There was no significant difference in the duration of operation,blood loss and fluid infusion volume between the two groups(P>0.05).The dosage of Sufentanil and the number of PCIA compression during operation in the observation group were significantly less than those in the control group,and the time to the first PCIA compression was significantly longer than that in the control group(P<0.01).The postoperative anal exhaust time,the time to off-bed activity and the length of hospital stay in the observation group were significantly shorter than those in the control group(P<0.01).The incidences of nausea,vomiting and respiratory depression in the observation group were significantly lower than those in the control group(P<0.05,P<0.01).Conclusion Bilateral TPVB combined with general anesthesia for laparoscopic PD is beneficial for maintaining hemodynamic stability of the body,reducing the dosage of Sufentanil during operation,reducing the risk of perioperative adverse reactions,and promoting postoperative recovery of patients.