Observation on the Efficacy of Danlong Oral Liquids Combined with Fu-dosteine Oral Liquids as Adjuvant Therapy for Mycoplasmal Pneumoniae Pneumonia
ZHANG Qian
MA Shiqing
WANG Danting
Abstract：Objective To investigate the effect of Danlong oral liquid combined with Fudosteine oral liquid as adju-vant therapy for mycoplasmal pneumonia pneumonia(MPP).Methods A total of 150 children with MPP who were treated in our hospital from January 2022 to May 2024 were selected and randomly divided into control group A(n=50),control group B(n=50),and combination group(n=50)by random number table method.The control group A was given Danlong oral liquid,the control group B was given Fudosteine oral liquid,and the combined group was given Danlong oral liquid combined with Fudosteine oral liquid.The clinical efficacy,disease recovery indicators,lung function[forced vital capacity(FVC),peak expiratory flow(PEF),forced expiratory volume in one second(FEV1)],inflammatory factors[interleukin(IL)-6,IL-17,C reactive protein(CRP)],immune function[immunoglobulin(Ig)M,IgG,IgA],Toll-like receptor 4/myeloid dif-ferentiation factor88/nuclear factor-κB(TLR4/MyD88/NF-κB)signaling pathway factors,and adverse reactions were com-pared among the three groups.Results The total effective rate of the combination group was[94.00%(47/50)],which was higher than that of the control group A[80.00%(40/50)]and control group B[76.00%(38/50)](P＜0.05).The improvement time of cough,expectoration,fever,and lung wet rale in the combination group was shorter than that in the con-trol group A and control group B(P＜0.05).After treatment,the FEV1,FVC,PEF,IgA,IgM,and IgG levels in the com-bination group were higher than those in the control group A and control group B,while the expression levels of IL-6,CRP,IL-17,TLR4,MyD88,and NF-κB were lower than those in the control group A and control group B(P＜0.05).There was no significant difference in the incidence of adverse reactions among the three groups(P＞0.05).Conclusion Danlong oral liquid combined with Fudosteine oral liquid as adjuvant therapy has significant effects in the treatment of MPP,which can im-prove lung function,ameliorate clinical symptoms,inhibit inflammatory reactions and the expression of TLR4/MyD88/NF-κB signaling pathway,enhance immune function,and have high safety.
Keywords：Danlong oral liquidFudosteine oral liquidPneumoniamycoplasmaForced expiratory volumeMaxi-mal expiratory flowInterleukin-6Immunoglobulin MTLR4/MyD88/NF-κB signaling pathwayChildren
Publication Date：2025-05-13
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 97-103 )