Relationship between Serum Hcy and UA Levels and the Risk of Hemor-rhage Transformation in Patients with Acute Ischemic Stroke
YUAN Meng
CHEN Fei
DU Yangxuan
YANG Yizhe
WANG Dan
NIU Xueyan
MENG Kai
Abstract：Objective To investigate the correlation between serum homocysteine(Hcy)and uric acid levels and the risk of hemorrhagic transformation(HT)in patients with acute ischemic stroke(AIS).Methods The clinical data of 120 patients with AIS admitted to our hospital from May 2021 to June 2024 were retrospectively analyzed.According to the pres-ence or absence of hemorrhagic transformation,the patients were divided into hemorrhagic transformation group(n=33)and non-hemorrhagic transformation group(n=87).Serum Hcy,uric acid levels and other general data were compared between the two groups.The receiver operating characteristic(ROC)curve was used to evaluate the predictive value of serum Hcy and uric acid for the risk of hemorrhagic transformation in patients with AIS.Multivariate logistic regression was used to analyze the influencing factors of hemorrhagic transformation risk in patients with AIS.Results The levels of serum Hcy and uric acid in the hemorrhagic transformation group were significantly higher than those in the non-hemorrhagic transformation group(P＜0.01).ROC curve analysis showed that the area under the curve(95%CI)of serum Hcy and uric acid alone and in combina-tion for predicting hemorrhagic transformation in patients with AIS was 0.850(0.800,0.900),0.866(0.816,0.916),0.906(0.856,0.956),respectively.Multivariate logistic regression analysis showed that,the National Institutes of Health Stroke Scale score＞16.22,serum C reactive protein＞11.14 mg/L,Hcy＞16.55 μmol/L,and uric acid＞355.85 μmol/L at admission were all risk factors for hemorrhagic transformation in patients with AIS(P＜0.01).Conclusion Abnormal increase of serum Hcy and uric acid levels are both risk factors for hemorrhagic transformation in patients with AIS,which can be used as effective indicators to evaluate the occurrence of hemorrhagic transformation in patients,and the combination of the two has higher predictive efficiency.
Keywords：Acute ischemic strokeHemorrhagic transformationHomocysteineUric acidNational Institutes of Health Stroke ScaleC reactive proteinRisk factors
Publication Date：2025-05-13
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 66-70,76 )