Meta-analysis of Risk Factors for Multidrug-Resistant Organism Infection in Patients with Diabetic Foot Wounds
MAO Senmiao
ZHANG Jianmeng
YANG Shaoling
CHENG Qi
Abstract：Objective To investigate the risk factors of multi-drug resistant organism(MDRO)infection in patients with diabetic foot wound.Methods A systematic search was conducted on Chinese Journal Full-Text Database CNKI,Wan-fang Data Resource System(Wanfang),Chinese Biomedical Literature Database(CBM),VIP database,PubMed,Web of Science,EmBase,The Cochrane Library,Ovid and Proquest for all literature on MDRO risk factors for diabetic foot wounds from inception until September 3,2024.Literature screening and data extraction were carried out according to the established criteria for literature inclusion and exclusion.Data such as the number of cases in the included literature and the risk factors of MDRO infection were extracted,and the risk factors of MDRO infection in patients with diabetic foot wound were combined and analyzed.Newcastle-Ottawa Scale(NOS)was used to evaluate the quality of research literature,and medium and high quality literature were selected.Meta-analysis was performed using RevMan 5.3 software.Results Finally,19 literatures were included,including 2 cohort studies and 17 case-control studies.A total of 8 638 cases were included,including 1 583 cases in the MDRO group and 7 055 cases in the non-MDRO group.The literature quality was medium to high.The results of Meta-analysis showed that osteomyelitis[OR=3.23,95%CI(2.62,3.99)],times of hospitalization for the same infection wound＞2 times/year[OR=2.60,95%CI(2.03,3.33)],antibiotic use history[OR=2.01,95%CI(1.80,2.25)],neuroischemic ulcer[OR=1.25,95%CI(1.16,1.34)],wound course[OR=1.34,95%CI(1.08,1.66)]and wound area[OR=1.48,95%CI(1.03,2.14)]were risk factors for MDRO infection in patients with diabetic foot wound(P＜0.05,P＜0.01).Conclusion Osteomyelitis,times of hospitalization for the same infection wound＞2 times/year,history of antibiotic application,neuroischemic ulcer,wound area and wound course are the main risk factors for MDRO infection in patients with diabetic foot wound.If these risk factors are present in the clinical diagnosis and treatment of diabetic foot,they should be corrected in time to promote wound healing.
Keywords：Diabetic footMultidrug-resistant organismRisk factorsOsteomyelitisHistory of antibiotic useNeu-roischemic ulcerWoundMeta-analysis
Publication Date：2025-05-13
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：8( 53-60 )