Effect of 28-Flavor Fengshi Gutong Powder Combined in the Treatment of Rheumatoid Arthritis of Cold-Dampness Arthralgia Type in Plateau Area and Its Impact on IGFBP-6
WANG Senlin
ZHANG Yonggang
ZHANG Ying
SHEN Kuo
ZHENG Guiping
LI Nan
SONG Xiaoxia
HAN Man
Abstract：Objective To observe the effect of combined treatment with 28-flavor Fengshi Gutong Powder on rheuma-toid arthritis(RA)of cold-dampness arthralgia type in plateau area and its effect on serum insulin-like growth factor binding protein-6(IGFBP-6).Methods From January 2021 to January 2023,60 patients with RA of cold-dampness arthralgia type in plateau areas were selected and divided into observation group and control group by random number table method,with 30 patients in each group.The control group was treated with Methotrexate,and the observation group was treated with 28-flavor Fengshi Gutong powder for 4 weeks.The clinical efficacy and adverse reactions of the two groups were compared,as well as the total traditional Chinese medicine(TCM)syndrome score,durtion of morning stiffness,number of joint tenderness,num-ber of joint swelling,C reactive protein(CRP),rheumatoid factor(RF),erythrocyte settlement rate(ESR),IGFBP-6 lev-el,and 28-joint disease activity score(DAS28)before and after treatment.Results The total effective rate of the observation group was 93.33%(28/30),which was significantly higher than that of the control group(60.00%,18/30),showing sig-nificant difference(P＜0.01).After treatment,the total TCM syndrome score,CRP,ESR,RF and DAS28 scores of the two groups were decreased,which were lower in the observation group than in the control group(P＜0.05,P＜0.01).After treatment,the duration of morning stiffness of the two groups was shortened,the number of joint tenderness and joint swelling was reduced,and the improvement of the above indexes in the observation group was better than that in the control group(P＜0.05).After treatment,the IGFBP-6 level of the two groups was increased,which was higher in the observation group than in the control group(P＜0.05,P＜0.01).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Combined treatment with 28-flavor Fengshi Gutong powder can significantly improve IGFBP-6 level,and ameliorate the disease and immune function of patients in the treatment of RA of cold-dampness arthralgia type in plateau area,with fewer adverse reactions.
Keywords：Rheumatoid arthritisPlateau areas28-flavor Fengshi Gustong powderInsulin-like growth factor bind-ing protein-6C reactive proteinRheumatoid factorDrug toxicity
Publication Date：2025-04-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 91-95 )