Expression of miR-217,USP10 and LZTS1 in Advanced Non-small Cell Lung Cancer Tissues and Adjacent Tissues and Their Relationship with Clinical Efficacy

XIE Fangfang; FAN Jing; LI Jianmei

doi:10.3969/j.issn.1002-3429.2025.08.014

Abstract：Objective To investigate the expression of microrNA-217(miR-217),ubiquitin-specific peptidase 10(USP10)and leucine zipper tumor suppressor gene 1(LZTS1)in advanced non-small cell lung cancer(NSCLC)tissues and adjacent tissues and their relationship with clinical efficacy.Methods A total of 108 patients with advanced NSCLC admitted from January 2021 to January 2023 were selected as the research subjects,and the levels of miR-217,USP10 and LZTS1 in cancer tissues and adjacent tissues were compared.All patients were given individualized treatment,and were divided into dis-ease control group and disease progression group based on the condition at 1-year follow-up.The clinical data and the lev-els of miR-217,USP10 and LZTS1 in cancer tissues of the two groups were compared,and the relationship between the levels of miR-217,USP10 and LZTS1 and clinical efficacy and its predictive value were analyzed.The 1-year survival rates of pa-tients with different levels of miR-217,USP10 and LZTS1 were compared.Results The mRNA levels of miR-217 and LZTS1 in cancer tissues of patients with advanced NSCLC were lower than those in adjacent tissues,and USP10 mRNA level was higher than that in adjacent tissues(P＜0.01).Among 108 patients with advanced NSCLC,44 patients with partial response and 33 patients with stable disease were included in the disease control group,and 31 patients with progression were included in the disease progression group.The miR-217 and LZTS1 mRNA levels in cancer tissues of the disease progression group were lower than those of the disease control group,and USP10 mRNA level was higher than that of the disease control group(P＜0.01).Multivariate logistic regression analysis showed that miR-217,USP10 and LZTS1 were independent factors af-fecting the clinical efficacy of advanced NSCLC patients before and after adjusting for other factors(P＜0.01).The combina-tion of miR-217,USP10,and LZTS1 in cancer tissues had a significantly higher value in predicting the disease progression of advanced NSCLC patients than each index alone(P＜0.05).Kaplan-Meier curve analysis showed that the 1-year survival rate of patients with low expression of miR-217 and LZTS1 was 35.00%(14/40)and 31.71%(13/41),which were lower than 69.70%(46/66)and 72.31%(47/65)of patients with high expression.The 1-year survival rate of patients with high ex-pression of USP10 was 32.61%(15/46),which was lower than 75.00%(45/60)of patients with low expression of USP10,showing significant differences(P＜0.05).Conclusion The expressions of miR-217 and LZTS1 are low,and USP10 is high in patients with advanced NSCLC.They are independently correlated with the clinical efficacy,can effectively predict clinical efficacy,and are closely related to survival prognosis.