Effect of Vitamin D Supplementation on Pulmonary Function in Children with Acute Exacerbation of Bronchial Asthma

WANG Hui; YANG Bo

doi:10.3969/j.issn.1002-3429.2025.08.013

Abstract：Objective To investigate the effect of vitamin D(VD)supplementation on pulmonary function in chil-dren with acute exacerbation of bronchial asthma.Methods Eighty children with acute exacerbation of bronchial asthma ad-mitted to the pediatric clinic from January 2021 to June 2022 were divided into the observation group and the control group ac-cording to random number table method,with 40 patients in each group.The control group was given Budesonide aerosol inha-lation on the basis of routine treatment,and the observation group was given vitamin D drops on the basis of the control group.Both groups were treated for 8 weeks.The disappearance time of clinical symptoms and signs,the levels of eosinophils(EOS),total immunoglobulin E(TIgE)and serum 25-hydroxyvitamin D3[25-(OH)D3]before and after treatment were com-pared between the two groups.Before and after treatment,forced expiratory volume in one second(FEV1),FEV1/forced vi-tal capacity(FEV1/FVC),peak expiratory flow(PEF),peak expiratory flow rate(PEFR),Childhood Asthma Control Test(C-ACT)score and Pediatric Quality of Life Inventory(PedsQL)Asthma Module score,as well as adverse reactions during treatment,were compared between the two groups.Results The disappearance time of asthma,cough,dyspnea and lung rales in the observation group were shorter than those in the control group(P＜0.01).After treatment,EOS and TIgE in the two groups were lower than those before treatment(P＜0.05),but there was no difference between the two groups(P＞0.05).After treatment,the level of 25-(OH)D3 in the observation group was higher than that before treatment and that in the control group(P＜0.05,P＜0.01).After treatment,the levels of FEV1,FEV1/FVC,PEF and PEFR in the two groups were higher than those before treatment,which were higher in the observation group than in the control group(P＜0.05,P＜0.01).After treatment,the C-ACT score and PedsQL Asthma Module score of the two groups were higher than those before treatment(P＜0.05),but there was no difference between the two groups(P＞0.05).During the treatment,the incidence of adverse reactions was20.00%(8/40)in the observation group and17.50%(7/40)in the control group,and the differ-ence was not significant(P＞0.05).Conclusion VD supplementation can significantly shorten the duration of clinical symptoms and signs and improve the pulmonary function of children with acute exacerbation of bronchial asthma,with good safety.