Effect of Combined Salmeteroticasone Powder Inhalant in the Treatment of Bronchial Asthma in Children and Its Effect on Inflammatory Factors
ZHAO Xiaoqian
GAO Yan
YANG Xiaoting
ZHANG Xiaoyu
Abstract：Objective To explore the effect of combined Salmeteroticasone powder inhalant in the treatment of bron-chial asthma in children and its effects on inflammatory factors.Methods Fifty children with bronchial asthma were selected from January 2023 to December 2023.According to random number table method,they were divided into CG group and OG group with 25 patients in each group.The children in the two groups were treated with routine treatment and spleen aminopep-tide oral lyophilized powder.On this basis,the CG group was given Budesonide formoterol powder inhalant,and the OG group was given Salmeteroticasone powder inhalant The clinical efficacy of the two groups was compared,as well as asthma control test(ACT)score,pulmonary ventilation function indicators[peak expiratory flow(PEF),forced vital capacity(FVC),forced expiratory volume in the first second(FEV1)],airway inflammation indicators[peripheral blood eosinophils percent-age(EOS%),eosinophils(EOS),interleukin-4(IL-4)],immune function indicators and factors associated with Toll-like receptor 4(TLR4)/nuclear factor-κB(NF-κB)signaling pathways before and after treatment.The incidence of adverse reac-tions was compared between the two groups.Results The total effective rate of clinical treatment in the OG group was 96.00%(24/25),which was higher than that in the CG group[80.00%(20/25)](P＜0.05).After treatment,the in-creases in ACT score,FVC,FEV1,PEF,CD4+/CD8+,CD3+and CD4+levels were all greater in the OG group than in the CG group(P＜0.05).After treatment,serum IL-4,peripheral EOS%,EOS levels and TLR4 and NF-κB mRNA expres-sion levels were reduced more significantly in the OG group than in the CG group(P＜0.05).There was no statistical differ-ence in the incidence of adverse reactions between the two groups during treatment(P＞0.05).Conclusion Treatment with Salmeteroticasone powder inhalant can effectively control the clinical symptoms of children with bronchial asthma,improve pul-monary function,reduce the release of inflammatory mediators,thus alleviating airway inflammation and improving immune function.The mechanism of its efficacy may be related to TLR4/NF-κB signaling pathway,which can provide ideas for subse-quent drug research.
Keywords：Bronchial asthmaChildSalmeteroticasone powder inhalantInterleukin-4Forced vital capacityIm-mune functionToll-like receptor 4Nuclear factor-кB
Publication Date：2025-04-13
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 67-72 )