Observation on the Clinical Effect of Qingre Jiedu Huatan Xiefei Decoction Combined with Azithromycin in the Treatment of Mycoplasma Pneumoniae Pneumonia in Children with Phlegm-Heat Blocking Lung Syndrome
WANG Fei
ZHAO Fuqiang
TONG Dan
HONG Yan
Abstract：Objective To investigate the clinical effect of Qingre Jiedu Huatan Xiefei decoction combined with Az-ithromycin in the treatment of mycoplasma pneumoniae pneumonia(MPP)in children with phlegm-heat blocking lung syn-drome and their impact on the scores of symptoms and signs and inflammatory factors.Methods In total,96 MPP children with phlegm-heat blocking lung syndrome treated from October 2023 to June 2024 were selected and divided into the control group(n=48)and the observation group(n=48)according to random number table method.Both groups were given con-ventional treatment,the control group was treated with Azithromycin,and the observation group was treated with Qingre Jiedu Huatan Xiefei decoction on the basis of the control group.The clinical efficacy,scores of symptoms and signs,inflammatory indicators[C reactive protein(CRP),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)]and improvement of chest CT lesions after treatment were observed in the two groups,and the occurrence of adverse reactions during treatment was ob-served.Results The total effective rate of the observation group[95.83%(46/48)]was higher than that of the control group[79.17%(38/48)],and the difference was statistically significant(P＜0.05).After treatment,the scores of symp-toms and signs,total scores and inflammatory indicators in the two groups were lower than those before treatment,and lower in the observation group than in the control group(P＜0.05,P＜0.01).After treatment,the total proportion of patients with lung consolidation,atelectasis,bronchial stenosis,and pleural effusion in both groups was lower than that in the control group,which was lower in the observation group than in the control group(P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusion In the treatment of MPP in children with phlegm-heat blocking lung syndrome,Qingre Jiedu Huatan Xiefei decoction combined with Azithromycin can effectively relieve clinical symptoms,reduce inflammatory reactions,promote the recovery of chest lesions,and improve clinical efficacy,with good safety.
Keywords：Qingre Jiedu Huatan Xiefei decoctionPhlegm-heat blocking lung syndromePneumoniamycoplasmaC reactive proteinInterleukin-6Tumor necrosis factor-αScores of symptom and signsChildren
Publication Date：2025-03-29
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 90-94 )