Prognostic Efficacy of Serum miR-34a and TLR4 Levels in SCOPD Patients
LI Qi
CAI Peifen
WANG Meng
Abstract：Objective To investigate the predictive efficacy of serum microRNA-34a(miR-34a)and Toll-like recep-tor 4(TLR4)on the prognosis of patients with stable chronic obstructive pulmonary disease(SCOPD).Methods A total of 107 patients with SCOPD admitted from February 2022 to February 2023 were retrospectively analyzed and followed up for 1 year.According to the clinical prognosis,the patients were divided into the good prognosis group(n=41)and the poor prog-nosis group(n=66),and the clinical data of the patients were collected to analyze the influencing factors leading to the oc-currence of poor prognosis.The predictive efficacy of serum miR-34a and TLR4 levels for poor prognosis of patients was evalu-ated.Results Compared with the good prognosis group,the poor prognosis group had significantly lower levels of FVC,FEV1,and FEV1/FVC and significantly higher levels of serum miR-34a and TLR4(P＜0.01).FVC,FEV1,FEV1/FVC,miR-34a and TLR4 levels were all influencing factors for poor prognosis of patients(P＜0.05,P＜0.01).The area under the curve of miR-34a combined with TLR4 to predict poor prognosis of SCOPD was 0.854,and the sensitivity and specificity were 86.36%and 78.05%,respectively(P＜0.01).Conclusion The levels of miR-34a and TLR4 are both influencing factors for the poor prognosis of patients with SCOPD,and they are effective indicators to predict the poor prognosis of patients.
Keywords：Pulmonary diseasechronic obstructiveMicroRNA-34aToll-like receptor 4Stable periodPrognosisForced vital capacityForced expiratory volume in one second
Publication Date：2025-03-29
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 43-48 )