Effect of Bupleurum Angelica Powder Combined with Tenofovir Alafe-namide in the Treatment of Liver Fibrosis in Patients with Chronic Hepati-tis B

ZHAO Caisha; KONG Hongbin; LI Weiqiang; LI Gaiye; PEI Xiaomin; ZHANG Yunhao

doi:10.3969/j.issn.1002-3429.2025.05.015

Abstract：Objective To explore the effect of Bupleurum Angelica powder combined with Tenofovir Alafenamide(TAF)in the treatment of liver fibrosis in patients with chronic hepatitis B(CHB).Methods A total of 100 CHB patients with liver fibrosis treated from October 202 1to October 2023 were selected and divided into the observation group(treated with Bupleurum Angelica powder combined with TAF,n=50)and the control group(treated with TAF alone,n=50)by random number table method.The therapeutic effect,hepatitis B virus(HBV)-DNA negative conversion rate and adverse reactions were compared between the two groups.Liver stiffness,inflammatory factors[matrix metalloproteinase-2(MMP-2),transfor-ming growth factor-β1(TGF-β1),interleukin-8(IL-8),tumor necrosis factor-α(TNF-α)],traditional Chinese medicine(TCM)syndrome score,intestinal flora level and the difference before and after treatment were also included.Results The total effective rate of the observation group was 96.00％(48/50),which was higher than that of the control group[82.00％(41/50),P＜0.05],and there was no significant difference in the negative conversion rate of HBV-DNA between the two groups(P＞0.05).After treatment,liver stiffness and levels of MMP-2,TGF-β1,IL-8 and TNF-α in the two groups were lower than those before treatment,and lower in the observation group than in the control group(P＜0.05,P＜0.01).The differences of liver stiffness,MMP-2,TGF-β1,IL-8 and TNF-α before and after treatment in the observation group were grea-ter than those in the control group(P＜0.01).After treatment,the TCM syndrome scores of the two groups were lower than those before treatment,and lower in the observation group than in the control group(P＜0.05,P＜0.01).The difference of TCM syndrome scores before and after treatment in observation group was greater than that in control group(P＜0.01).After treatment,the colony number of enterococcus and Escherichia coli in observation group was lower than that before treatment and that in the control group,while the colony number of lactobacillus and bifidobacterium was higher than that before treat-ment and that in the control group(P＜0.05,P＜0.01).The difference of colony number of enterococcus,Escherichia coli,Lactobacillus and bifidobacterium in the observation group before and after treatment was greater than that in the control group(P＜0.01).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Con-clusion Bupleurum Angelica powder combined with TAE in the treatment of liver fibrosis in patients with chronic hepatitis B is effective,which can improve clinical symptoms,liver stiffness,inhibit inflammatory response,and improve intestinal flora,without affecting the safety of treatment.