Relationship of BMI and Serum sIgE Level with Pulmonary Function and Therapeutic Effect in Children with Acute Exacerbation of Allergic Asthma
WANG Mengmeng
LI Jingpeng
WANG Genxiang
WEI Hong
LI Xuejun
Abstract：Objective To explore the relationship of body mass index(BMI)and serum specific immunoglobulin E(sIgE)levels with pulmonary function and therapeutic effect in children with acute exacerbation of allergic asthma.Methods A total of 120 children with acute exacerbation of allergic asthma were selected from the pediatric outpatient department from January 2022 to January 2024.According to the growth curve of BMI of Chinese children and adolescents aged 0 to 18 years,they were divided into obesity group(n=30),overweight group(n=30)and non-obesity group(n=60).According to the total serum sIgE level,they were dibided into strongly positive group(n=35),positive group(n=57)and negative group(n=28).All children were given standardized treatment for asthma for 4 months.After treatment,the therapeutic effect and the levels of pulmonary function[the forced expiratory volume in one second(FEV1),forced vital capacity(FVC)and peak expiratory flow rate(PEF)]before and after treatment were compared in all groups.Pearson correlation analysis was used to analyze the correlation between BMI,serum sIgE and pulmonary function.Results After treatment,the total effective rate of obesity group and overweight group was lower than that of non-obesity group(P＜0.05),and the total effective rate of strongly positive group and positive group was lower than that of negative group(P＜0.05).After treatment,FEV1,FVC and PEF were higher than those before treatment(P＜0.05).After treatment,FEV1,FVC and PEF in overweight and obesity groups were lower than those in non-obesity group,while FEV1,FVC and PEF in obesity group were lower than those in overweight group(P＜0.01).After treatment,FEV1,FVC and PEF in strongly positive group and positive group were lower than those in negative group,while FEV1,FVC and PEF in strongly positive group were lower than those in positive group(P＜0.05).Pearson correlation analysis showed that BMI and serum sIgE levels were negatively correlated with pulmonary function indexes FEV1,FVC and PEF in children with acute exacerbation of allergic asthma(P＜0.01).Conclusion The increase of BMI and serum sIgE levels is associated with impaired pulmonary function in children with acute exacerbation of allergic asthma,and affects the standardized treatment effect.
Keywords：Allergic asthmaAcute exacerbation stageChildrenBody mass indexSpecific immunoglobulin EObesityForced expiratory volume in one secondForced vital capacity
Publication Date：2025-03-14
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 53-58 )