Effect of Autologous Epidermal Transplantation Combined with Total Glu-cosides of White Paeony Capsules and Platelet-rich Plasma in the Treat-ment of Stable Vitiligo

WANG Zhan; HAN Li; WANG Qing; HAN Hongbin; JIANG Lihua

doi:10.3969/j.issn.1002-3429.2025.05.010

Abstract：Objective To observe the clinical effect of autologous epidermal transplantation combined with total glu-cocides of paeony capsules and intradermal injection of platelet-rich plasma(PRP)in the treatment of stable vitiligo.Meth-ods A total of 82 patients with stable vitiligo from June 2020 to March 2023 were selected and divided into two groups by ran-dom number table method.The 42 patients in the observation group were treated with autologous epidermal transplantation combined with oral administration of total glucosides of paeony capsules at 1 month before surgery and at 3 months after surgery and intradermal injection of PRP.During the treatment period,a total of 8 PRP intradermal injections were completed.Anoth-er 40 patients in the control group were treated with autologous epidermal transplantation combined with oral administration of total glycosides of paeony capsules at 1 month before surgery and at 3 months after surgery.Both groups were followed up for 6 months after 12 weeks of treatment to evaluate the therapeutic effect,and to compare the dermatological life quality index(DLQI)and the incidence of adverse reactions before and after treatment.Results The total effective rate was 92.86％(39/42)in the observation group,which was higher than that[75.00％(30/40)]in the control group,showing significant difference(P＜0.05).At 12 weeks after treatment and 6 months after follow-up,DLQI score of observation group was signifi-cantly lower than that of control group(P＜0.01).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Autologous epidermal transplantation combined with total glycosides of paeony capsules and intradermal injection of PRP can effectively promote the regression of white spots and improve the quality of life of patients with stable vitiligo,showing high safety.