Effect of Timing of Laparoscopic Minimally Invasive Surgery on the Effica-cy of Patients with Infectious Pancreatic Necrosis
ZHAO Qingtao
CUI Xin
WANG Jingzhou
WANG Yupeng
LIU Hangcheng
Abstract：Objective To explore the effect of different timing of laparoscopic minimally invasive surgery on the effi-cacy of patients with infectious pancreatic necrosis(IPN).Methods A total of 90 IPN patients treated from June 2020 to June 2023 were selected and divided into the early surgery group(days 1-3,n=48)and the late surgery group(days 4-7,n=42)according to the different timing of laparoscopic minimally invasive surgery.The scores of acute physiology and chron-ic health status score Ⅱ(APACHE Ⅱ),inflammatory factors and immune function indexes,as well as the incidence of post-operative complications and mortality,were compared between the two groups.Results The duration of surgery,postopera-tive exhaust time,postoperative diet recovery time and the length of hospital stay in the early surgery group were shorter than those in the late surgery group(P＜0.05,P＜0.01).All the scores of all dimensions of APACHE Ⅱ were decreased in the two groups after surgery,which were lower in the early surgery group than in the late surgery group(P＜0.05,P＜0.01).The levels of neutrophil to lymphocyte ratio,C reactive protein and interleukin-6 in the two groups were decreased after surgery,which were significantly lower in the early surgery group than in the late surgery group(P＜0.05,P＜0.01).After surgery,the levels of CD3+and CD4+were increased,while the levels of CD8+were decreased in both groups;the levels of CD8+in the early surgery group were significantly lower than those in the late surgery group,while the levels of CD3+and CD4+were significantly higher than those in the late surgery group(P＜0.05,P＜0.01).The incidence of postopera-tive complications[27.08％(13/48)]and mortality[2.08％(1/48)]in early surgery group were lower than those in late surgery group[50.00％(21/42)and 14.29％(6/42)](P＜0.05).Conclusion Early laparoscopic minimally invasive surgery for IPN has good clinical effects,which can significantly reduce inflammatory injury,improve immune function,short-en the length of hospital stay,and reduce postoperative complications with high safety.
Keywords：Infected pancreatic necrosisLaparoscopic minimally invasive surgeryTiming of surgeryDuration of surgeryC reactive proteinCD3+Postoperative complication
Publication Date：2025-03-14
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 37-41 )