Effect of Tongfu Chinese Medicine Combined with Western Medicine in the Treatment of Cerebral Edema After Cerebral Hemorrhage and Its Impact on Inflammatory Response,Edema Markers and Functional Prog-nosis

ZHOU Shengnan; SONG Yating; WANG Xuxin; MA Shaojin; GAO Liying

doi:10.3969/j.issn.1002-3429.2025.04.018

Abstract：Objective To explore the effect of Tongfu Chinese medicine combined with Western medicine in the treatment of cerebral edema after cerebral hemorrhage and its impact on inflammatory response,edema markers and functional prognosis.Methods A total of 102 patients with cerebral edema after cerebral hemorrhage admitted from May 2022 to May 2024 were divided into Western medicine group(n=51)and combination group(n=51)by random number table method.The Western medicine group was treated with conventional Western medicine,and the combination group was treated with Tongfu Chinese medicine combined with Western medicine for 14 d.Edema volume,intracranial pressure,Glasgow Coma Scale(GCS)score,National Institutes of Health Stroke Scale(NIHSS)score,inflammatory response indexes[nuclear tran-scription factor-κB(NF-κB),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),C-reactive protein(CRP)],edema markers[matrix metalloproteinase-9(MMP-9),aquaporin 4(AQP4)]before and after treatment,clinical efficacy,function-al prognosis[Modified Rankin Scale(mRS)],and occurrence of adverse reactions between the two groups were compared.Results At 3 and 14 d after treatment,the edema volume,intracranial pressure and NIHSS scores in the combination group were lower than those in the Western medicine group,while the GCS scores were higher than those in the Western medicine group(P＜0.05).At 3 and 14 d after treatment,serum TNF-α,CRP,IL-6 and NF-κB in the combination group were lower than those in the Western medicine group(P＜0.05).At 3 and 14 d after treatment,serum MMP-9 and AQP4 in combina-tion group were lower than those in Western medicine group(P＜0.05).The total effective rate of the combination group was 98.04%(50/51),which was higher than that of the Western group 84.31%(43/51,P＜0.05).At 3 months after treat-ment,the excellent and good rate of functional prognosis of the combination group was 94.12%(48/51),which was higher than that of the Western medicine group78.43%(40/51,P＜0.05).There was no significant difference in the incidence of adverse reactions between the combination group and the Western medicine group(P＞0.05).Conclusion Tongfu Chinese medicine combined with Western medicine has a remarkable effect in the treatment of cerebral edema after cerebral hemor-rhage,which can effectively reduce cerebral edema,improve nerve function,inhibit inflammatory response,and improve the quality of functional prognosis of patients.