Observation on the Clinical Effect of Liujunzi Decoction Combined with Shenqi Pills in the Treatment of Chronic Glomerulonephritis with Spleen-kidney Qi Deficiency Syndrome

ZHANG Ren; MIAO Yue; NI Guozhong

doi:10.3969/j.issn.1002-3429.2025.04.017

Abstract：Objective To evaluate the clinical effect of Liujunzi decoction combined with Shenqi pills in the treat-ment of chronic glomerulonephritis(CGN)with spleen-kidney qi deficiency syndrome.Methods A total of 116 CGN pa-tients with spleen-kidney qi deficiency syndrome treated from December 2021 to January 2024 were selected and divided into the observation group(n=58)and the control group(n=58)according to random number table method.The control group was given routine treatment to control blood pressure,blood lipids and proteinuria according to clinical manifestations,and the observation group was given the treatment of Liujunzi decoction combined with Shenqi pills on the basis of the control group.The two groups were treated consecutively for 8 weeks.The clinical efficacy,traditional Chinese medicine(TCM)syndrome score,renal function indexes[blood urea nitrogen(BUN),serum creatinine(Scr),24 h urinary protein quantity(24 h-Upro)]and inflammatory factor indexes[serum tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),hypersensitive C reactive protein(hs-CRP)]levels of the two groups before and after treatment were observed,and the occurrence of adverse reactions during treatment in the two groups was recorded.Results The total effective rate of the observation group was 94.83%(55/58),which was higher than that of the control group75.86%(44/58,P＜0.05).After treatment,the TCM syndrome score,BUN,Scr,24 h-Upro and serum hs-CRP,IL-6 and TNF-α levels in the two groups were lower than those be-fore treatment,and lower in the observation group than in the control group(P＜0.05).There were no obvious adverse reac-tions during treatment in both groups.Conclusion Liujunzi decoction combined with Shenqi pills has good clinical effect in the treatment of CGN patients with spleen-kidney qi deficiency syndrome,which can improve clinical symptoms,renal function and inflammatory response to a certain extent,and has certain safety.