Effects of Tripterygium Glycoside Tablets Combined with Bailing Capsule on TCM Syndrome Score,Adipocytokines and Renal Fibrosis in Patients with Stage Ⅳ Diabetic Nephropathy
ZUO Jianjiao
WEI Xuan
LI Gang
WANG Jin
LI Yuchan
SHI Yuntao
ZHANG Xiaoya
Abstract：Objective To investigate the effects of Tripterygium Glycoside tablets combined with Bailing capsule on traditional Chinese medicine(TCM)syndrome score,adipocytokines and renal fibrosis in patients with stage Ⅳ diabetic ne-phropathy(DN).Methods A total of 80 patients with stage Ⅳ DN treated from January 2017 to June 2021 were selected and divided into Bailing group(n=40)and combination group(n=40)according to different treatment methods.The two groups were given conventional treatment,the Bailing group was given Bailing capsule,and the combination group was given Bailing capsule combined with Tripterygium Glycoside tablets.TCM syndrome scores,serum adiponectin,Chemerin,cystatin C(CysC)and serum and urine transforming growth factor-β1(TGF-β1)levels were compared between the two groups before treatment and at 6 months after treatment.The occurrence of adverse reactions in the two groups was compared.Results Af-ter treatment,the TCM syndrome scores for shortness of breath,weakness of waist and knees,numbness of limbs and edema in combination group were lower than those before treatment and in Bailing group(P＜0.05).After treatment,the serum adi-ponectin level in combination group was higher than those before treatment and in Bailing group(P＜0.05).After treatment,the levels of Chemerin,CysC and TGF-β1 in serum and urine in combination group were lower than those before treatment and in Bailing group(P＜0.05).In combination group,there were 2 patients with liver injury and 1 patient with myelosuppres-sion(leukopenia)during treatment,all of which were mild and improved after corresponding intervention.No adverse reaction was reported in the Bailing group.Conclusion Tripterygium Glycoside tablets combined with Bailing capsule in the treatment of patients with stage Ⅳ DN can alleviate the TCM syndrome,regulate the levels of serum adiponectin and Chemerin,and have a significant effect on the improvement on renal fibrosis.
Keywords：Diabetic nephropathyTripterygium Glycoside tabletsBailing capsuleTraditional Chinese medicine syndromeAdiponectinChemerinCystain CTransforming growth factor-β1
Publication Date：2025-02-27
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 83-87 )