Serum Levels of Total Calciprotein Particles,Osteopontin,Homocysteine and Their Correlation with Vascular Calcification in Patients with Chronic Kidney Disease
DONG Liming
LI Benhao
LI Li
Mikereyi Aizimaiti
LI Yinhui
Abstract：Objective To analyze the serum levels of total calciprotein particles(TCPP),osteopontin(OPN)and homocysteine(Hcy)in patients with chronic kidney disease(CKD),their correlation with vascular calcification and their predictive efficacy.Methods A total of 120 patients with CKD admitted from August 2022 to August 2023 were selected as the research subjects,and were divided into the calcification group(n=40)and the non-calcification group(n=80)accord-ing to occurrence of vascular calcification.The baseline data and levels of serum biochemical indexes calcium,phosphorus,TCPP,OPN and Hcy)of the two groups were compared,and the correlation between serum TCPP,OPN and Hcy and vascu-lar calcification in patients with CKD was analyzed.Results There was no significant difference in gender,combined hyper-tension,combined diabetes,smoking history,drinking history,body mass index,primary disease and other baseline data be-tween the two groups(P＞0.05).The levels of serum calcium,phosphorus,TCPP,OPN,Hcy and the proportion of patients aged≥65 years in calcification group were higher than those in non-calcification group(P＜0.01).Logistic regression analy-sis showed that age,calcium,phosphorus,TCPP,OPN and Hcy were independent risk factors for vascular calcification in pa-tients with CKD(P＜0.01).The analysis of receiver operating characteristic(ROC)curve showed that the area under the ROC curve(AUC)of serum TCPP,OPN,and Hcy,alone and in combination,for the prediction of vascular calcification in patients with CKD was 0.801,0.824,0.803 and 0.932,respectively,showing certain predictive value.The AUC of the above indicators in combination for the diagnosis was significantly greater than that predicted by TCPP,OPN and Hcy alone(P＜0.01).Serum TCPP,OPN and Hcy were significantly and positively correlated with calcium and phosphorus in CKD pa-tients with vascular calcification(P＜0.01).Conclusion Serum levels of TCPP,OPN and Hcy are abnormally elevated in CKD patients with vascular calcification,which is closely related to the occurrence of vascular calcification.
Keywords：Chronic kidney diseaseVascular calcificationCalciprotein particleOsteopontinHomocysteineRisk factorPredictive valueCorrelation
Publication Date：2025-02-27
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 60-65 )