Diagnostic Value of Maternal Serum Immunoglobulin G Anti-A/B Antibody Combined with Cord Blood Total Bilirubin for Hemolytic Disease of Newborns
JI Xiaojun
ZHANG Mingmin
CHEN Yuanyuan
Abstract：Objective To investigate the diagnostic value of maternal serum immunoglobulin G(IgG)anti-A/B anti-body combined with neonatal total serum bilirubin(TSB)in umbilical cord blood in hemolytic disease of the newborn(HDN).Methods A total of 82 HDN neonates with incompatibility between maternal and fetal blood admitted from April 2019 to April 2024 were selected as the observation group,and 77 healthy neonates with incompatibility between maternal and fetal blood during the same period were selected as the control group.The titer of serum IgG anti-A/B antibody and TSB in umbilical cord blood before delivery were compared between the two groups.Receiver operating characteristic(ROC)curve was drawn to analyze the diagnostic value of IgG antibody titer,TSB in umbilical cord blood and their combination for HDN.Results The proportion of maternal serum IgG anti-A/B antibody titers≤1∶32 and 1∶64 in observation group[3.66%(3/82),8.54%(7/82)]was lower than that in control group[48.05%(37/77),24.68%(19/77)],and the proportion of 1∶256 and≥1∶512 in observation group[31.71%(26/82),35.37%(29/82)]was higher than that in control group[5.19%(4/77),3.90%(3/77)],showing significant differences(P＜0.05).The level of TSB in umbilical cord blood of observation group[(34.38±7.28)μmol/L]was higher than that of control group[(23.96±5.73)μmol/L],showing sig-nificant differences(P＜0.05).ROC curve analysis showed that the efficacy of serum IgG anti-A/B antibody titer and TSB in umbilical cord blood in combination for the diagnosis of HDN was higher than that of single diagnosis,with the sensitivity of 90.22%,the specificity of 89.56%,and the area under the ROC curve of 0.936.Conclusion The diagnostic value of ma-ternal IgG anti-A/B antibody combined with TSB in umbilical cord blood for HDN is higher.
Keywords：Immunoglobulin GAnti-A/B antibodyIncompatibility between maternal and fetal bloodFetal bloodBilirubinHemolytic disease of the newbornReceiver operating characteristic curveDiagnostic value
Publication Date：2025-02-14
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 78-82 )