Risk Factors for Methicillin-Resistant Staphylococcus Aureus in Patients with Diabetic Foot Wounds:A Meta-analysis
MENG Guangzhe
YANG Shaoling
HU Liye
XU Sijia
WANG Xiuhui
ZHU Lvyun
Abstract：Objective To investigate the risk factors of methicillin-resistant Staphylococcus aureus(MRSA)infection in patients with diabetic foot wound.Methods PubMed,Web of Science,EmBase,The Cochrane Library and Scopus,Pre-view,Ovid,Proquest,China Journal Full-text Database,China Biomedical Literature Database,Wanfang Data Resource Sys-tem and VIP database were systemically searched for all the literature on the risk factors of MRSA infection in patients with di-abetic foot wounds from the inception of the database to June 1,2024.After rigorous literature screening and exclusion,the literature quality was evaluated using Newcastle-Ottawa scale(NOS)for the included literature.The literature data and data extraction were carried out for each literature,including the number of cases and the risk factors of MRSA infection in the in-cluded literature,and the risk factors of MRSA infection in diabetic foot wound were analyzed.Meta-analysis was performed using RevMan 5.3 software.Results Ultimately,9 literature of medium or high quality were included,including 2 cohort studies and 7 case-control studies.A total of 1 193 patients were included,including 324 patients in MRSA group and 869 pa-tients in methicillin-sensitive Staphylococcus aureus(MSSA)group.Meta-analysis results showed that hypoproteinemia,his-tory of antibiotic use,ulcer area and osteomyelitis were risk factors for MRSA infection of diabetic foot wound(P＜0.01).Conclusion Hypoproteinemia,history of antibiotic use,ulcer area and osteomyelitis are the main risk factors for MRSA in-fection of diabetic foot wound,which should be corrected in time during clinical diagnosis and treatment.
Keywords：Diabetic footMethicillin-resistant staphylococcus aureusHypoproteinemiaOsteomyelitisHistory of antibiotic useUlcer areaRisk factorsMeta-analysis
Publication Date：2025-02-14
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 54-60 )