Correlation between Serum TRAF3 Expression and Pancreatic Islet Func-tion and Insulin Resistance in Patients with Type 2 Diabetes Mellitus
MENG Ke
YIN Dong
LI Juan
LI Yabing
DU Likun
Abstract：Objective To investigate the correlation between serum tumor necrosis factor receptor-associated factor 3(TRAF3)expression and islet function and insulin resistance(IR)in patients with type 2 diabetes mellitus(T2DM).Methods A total of 148 patients with T2DM treated from August 2022 to December 2023 were selected and divided into non-IR group(n=75)and IR group(n=73)according to the homeostatis model assessment-insulin resistance index(HOMA-IR).Another 80 healthy physical examinees were selected as control group.The expression level of serum TRAF3 was determined by enzyme-linked immunosorbent assay(ELISA).The correlation between serum TRAF3 expression levels and fasting insulin(FINS),2-hour postprandial blood glucose(2 h PG),homeostasis model assessment of β-cell function(HOMA-β)and insulin sensitivity index(ISI)was analyzed by Pearson and Spearman methods.The factors affecting IR in T2DM patients were analyzed by multiple linear regression analysis,and the predictive value of serum TRAF3 expression level in IR in T2DM patients was analyzed by receiver operating characteristic(ROC)curve.Results The serum TRAF3 level of T2DM patients was higher than that of healthy subjects,and the serum TRAF3 level in non-IR group was lower than that in IR group(P＜0.01).There were significant differences in FINS,triacylglycerol,low density lipoprotein cholesterol(LDL-C),glycosylated hemoglobin(HbA1c),fasting plasma glucose(FPG),2 h PG,HOMA-IR,HOMA-β and ISI between non-IR and IR groups(P＜0.05,P＜0.01).Serum TRAF3 levels in T2DM patients were significantly and positively correlated with FINS,2 h PG,HOMA-β and FPG(P＜0.05).The results of multiple linear regression analysis showed that TRAF3,FINS,FPG,2 h PG,LDL-C and HbA1c were the influencing factors of IR in T2DM patients(P＜0.05,P＜0.01).ROC curve analysis results showed that the area under the ROC curve of serum TRAF3 expression level to evaluate IR in T2DM patients was 0.818,and the sensitivity and specificity were 78.08%and 73.00%,respectively.Conclusion The expression level of serum TRAF3 is closely related to islet function and IR in T2DM patients.
Keywords：Diabetes mellitustype 2Tumor necrosis factor receptor associated factor 3Pancreatic islet functionInsulin resistanceFasting blood glucoseInsulin levelLow density lipoprotein cholesterolGlycosylated hemoglobin
Publication Date：2025-02-14
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 47-53 )