Monitoring of Peripheral Neurotoxic Adverse Effects of Taxane Antitumor Drugs and Analysis of Influencing Factors

NIE Penghao; CHENG Qingrong

doi:10.3969/j.issn.1002-3429.2025.01.009

Abstract：Objective To monitor peripheral neurotoxic adverse effects of Taxane antitumor drugs and to analyze the influencing factors.Methods A total of 180 patients receiving chemotherapy with Taxane antitumor drugs from January 2020 to December 2023 were selected as the research subjects and divided into occurrence group and non-occurrence group accord-ing to presence or absence of peripheral neurotoxic adverse reactions.The clinical data of patients were analyzed,and the oc-currence of peripheral neurotoxic adverse reactions during treatment was observed.The influencing factors of peripheral neuro-toxic adverse reactions in patients treated with Taxane antitumor drugs were analyzed by multivariate logistic regression.Re-sults The incidence of peripheral neurotoxic adverse reactions was 31.11%(56/180)in patients treated with Taxane antitu-mor drugs,mainlyⅠ-Ⅱdegree,accounting for92.86%(52/56).The main clinical manifestations of peripheral neurotoxic adverse reactions were extremity numbness,fatigue and tactile change,which mainly occurred at 12-＜72 h after medication,and the highest incidence was found at 24-＜48 h after medication.Older age,combined diabetes mellitus,higher clinical stage,higher cumulative dose of chemotherapy drugs,and more severe liver function injury were the risk factors for peripheral neurotoxic adverse reactions in patients treated with Taxane antitumor drugs(P＜0.01).Conclusion The incidence of pe-ripheral neurotoxic adverse reactions of Taxane antitumor drugs was relatively high,mainly mild reactions.Older age,diabetes mellitus,higher clinical stage,higher cumulative dose of chemotherapy drugs and more severe liver function injury are high risk factors,which should be paid clinical attention and preventive measures should be formulated.