Clinical Features and Levels of Tumor Markers in Patients with Different Types of Interstitial Lung Diseases and Influencing Factors for the Occur-rence of Lung Cancer
LI Xiuze
WANG Jing
XING Yanping
LIU Xiao
LIU Yue
Abstract：Objective To explore the clinical features,tumor marker levels in patients with different types of intersti-tial lung disease(ILD)and influencing factors of the occurrence of lung cancer,so as to improve the early diagnosis rate of patients combined with lung cancer and avoid delayed diagnosis.Methods A total of 335 patients with ILD admitted from January 2020 to December 2022 were selected.According to the high-resolution CT findings and laboratory examination,the patients were divided into idiopathic pulmonary fibrosis(IPF)group(n=106),non-IPF group(n=124),and connective tissue disease-associated ILD(CTD-ILD)group(n=105).General data,incidence of lung cancer,serum tumor markers[carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA125),neuron-specific enolase(NSE),cytokeratin-19 fragment antigen 21-1(CYFRA21-1),squamous cell carcinoma antigen(SCC),and pro-gastrin-releasing peptide(ProGRP)]were compared among the three groups.Multivariate logistic regression analysis was used to analyze the risk fac-tors affecting the occurrence of lung cancer.Results The levels of CEA,CA125,NSE and CYFRA21-1 in IPF group were higher than those in non-IPF group and CTD-ILD group(P＜0.05),and there were no significant differences in serum SCC and ProGRP in IPF group(P＞0.05).The incidence of lung cancer in IPF group was 55.66%(59/106),which was higher than that in non-IPF group[18.55%(23/124)]and CTD-ILD group[23.81%(25/105)](P＜0.05).The proportion of patients with ILD≥60 years,smoking,coughing sputum and hemoptysis were higher than those without lung cancer(P＜0.05).Age≥60 years,smoking and IPF were the risk factors for lung cancer in patients with ILD(P＜0.05).Conclusion IPF patients had the highest proportion of lung cancer,and serum CEA,CA125,NSE,and CYFRA21-1 levels were higher than those of non-IPF and CTD-ILD patients.Clinical attention should be paid to patients with ILD with risk factors such as age≥60 years,smoking,and IPF,which can effectively improve the early diagnosis rate of complicated lung cancer and avoid delayed diagnosis.
Keywords：Interstitial lung diseaseIdiopathic pulmonary fibrosisLung cancerCarcinoembryonic antigenCarbo-hydrate antigen 125Neuron-specific enolaseCytokeratin-19 fragment antigen 21-1Risk factor
Publication Date：2025-01-14
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 30-34 )