Clinical Effect of Ulinastatin Combined with Sequential Dialysis and Con-tinuous Hemofiltration on Severe Acute Pancreatitis and Septic Shock
HAN Wenjun
LI Xiaofan
LI Xin
SHI Lina
LIN Lina
LI Youliang
WANG Yan
XU Dandan
Abstract：Objective To analyze the effect and safety of Ulinastatin combined with sequential dialysis and continu-ous hemofiltration in the treatment of severe acute pancreatitis and septic shock.Methods From January 2021 to December 2023,76 patients with severe acute pancreatitis and septic shock were selected and divided into groups according to different treatment methods.Thirty-eight patients in the control group received Ulinastatin treatment,and 38 patients in the observation group was supplemented with sequential dialysis and continuous hemofiltration treatment on the basis of the control group.The treatment status,adverse reactions,acute physiological and chronic health evaluation scoring systemⅡ(APACHEⅡ),inter-leukin-6(IL-6),interleukin-8(IL-8),high mobility group box-1 protein(HMGB1)and obestatin levels before and after treatment were compared between the two groups.Results Recovery time of blood amylase,gastrointestinal function and urine amylase and the length of hospital stay in the observation group were shorter than those in the control group,and the in-cidence of adverse reactions was lower than that in the control group(P＜0.05).At 12,24 and 72 h after treatment,APACHEⅡ scores in the two groups were lower than those before treatment,and the observation group had lower scores than the control group(P＜0.05).After treatment,the levels of IL-6,IL-8,HMGB1 and obestatin in the two groups were lower than those before treatment,and the observation group had lower levels than the control group(P＜0.05).Conclusion Uli-nastatin combined with sequential dialysis and continuous hemofiltration is effective in the treatment of severe acute pancreatitis and septic shock,which can reduce adverse reactions and APACHEⅡscores,and alleviate inflammatory reactions,thus im-proving the prognosis of patients and enhancing drug safety.
Keywords：PancreatitisacuteSeptic shockUlinastatinSequential dialysisHemofiltrationInterleukin-6High mobility group box-1 proteinObestatin
Publication Date：2024-12-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 87-90 )