Levels of SAA,TNF-α and LTB4 in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease and Their Correlation Analysis
GAO Yan
ZHANG Nan
XU Dandan
YANG Xiaoting
WANG Yan
Abstract：Objective To investigate the changes in serum amyloid A(SAA),tumor necrosis factor-α(TNF-α)and leukotriene B4(LTB4)levels in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)and their correlation,so as to improve the early diagnosis rate of AECOPD and prevent clinical misdiagnosis.Methods Fifty-five patients with AECOPD admitted to our hospital from September 2022 to December 2023 were selected as the observation group,and 55 healthy patients who presented to our hospital for physical examination during the same period were selected as the control group.The serum levels of SAA,TNF-α,and LTB4 in the observation group at admission,during remission,and in the control group were analyzed,and the serum levels of SAA,TNF-α,and LTB4 in patients of different severity before treatment were recorded.SAA,TNF-α,and LTB4 levels in the remission group and non-remission group,as well as the cor-relation between the serum levels of SAA and TNF-α,and LTB4 in the observation group were observed.Results In the ob-servation group,the serum levels of SAA,TNF-α and LTB4 were significantly higher than those in the control group at admis-sion and during remission(P＜0.05),while the serum levels of SAA,TNF-α and LTB4 in remission stage were significantly lower than those at admission(P＜0.05).The serum levels of SAA,TNF-α and LTB4 in non-respiratory failure group before treatment were significantly lower than those in respiratory failure group(P＜0.05),and the serum levels of SAA,TNF-α and LTB4 in remission group were significantly lower than those in non-remission group(P＜0.05).The serum levels of SAA were positively correlated with TNF-α and LTB4 in the observation group(r=0.256,0.482,P＜0.05).Conclusion The serum levels of SAA,TNF-α and LTB4 in AECOPD patients are significantly increased,and the serum levels of SAA,TNF-α and LTB4 in AECOPD patients with different disease severity and therapeutic effects are significantly different.Detection of the above indicators can improve the diagnosis rate of AECOPD,and prevent the occurrence of misdiagnosis.
Keywords：Pulmonary diseaseChronic obstructiveAcute exacerbation stageSerum amyloid ATumor necrosis factor-αLeukotriene B4Diagnostic valueCorrelation
Publication Date：2024-12-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 31-35 )