Correlation of Sigma-1 Receptor with Cognitive Function and Clinical Effi-cacy of Donepezil Hydrochloride in Alzheimer's Disease

XI Yang; LI Hailing

doi:10.3969/j.issn.1002-3429.2024.19.012

Abstract：Objective To investigate the expression level of serum Sigma-1 receptor in patients with Alzheimer's dis-ease(AD)and to analyze its potential clinical value.Methods Eighty patients with mild-to-moderate AD admitted from March 2022 to December 2023 were randomly divided into cognitive training group(cognitive function training)and Donepezil group(cognitive function training combined with Donepezil Hydrochloride),with 40 patients in each group,and 40 healthy physical examinees were selected as healthy control group during the same period.Serum Sigma-1 receptor levels,Montreal Cognitive Assessment Scale(MoCA)and Mini-mental State Examination Scale(MMSE)scores of all health controls were measured on the day of physical examination.Before and at 8 weeks after treatment,serum Sigma-1 receptor levels and scores of MoCA,MMSE,Clinical Dementia Rating Scale(CDR)and Activities of Daily Living Rating Scale(ADL)in the cognitive training group and Donepezil group were detected.Pearson correlation analysis was used to analyze the correlation between ser-um Sigma-1 receptor level and MoCA,MMSE,ADL and CDR scores after treatment.Results Serum Sigma-1 receptor,MoCA and MMSE scores in cognitive training group and Donepezil group were decreased compared with healthy control group(P＜0.05),but there was no significant difference between cognitive training group and Donepezil group(P＞0.05).After treatment,serum Sigma-1 receptor,MoCA,MMSE and ADL scores in Donepezil group were higher than those before treat-ment and those in cognitive training group,while CDR scores were lower than those before treatment and those in cognitive training group(P＜0.05).After treatment,serum Sigma-1 receptor in AD patients was positively correlated with MoCA,MMSE and ADL scores,but negatively correlated with CDR scores(P＜0.01).Conclusion The level of serum Sigma-1 re-ceptor is related to cognitive function in AD patients.Treatment with Donepezil Hydrochloride can increase the expression of serum Sigma-1 receptor and improve the memory and cognitive function of patients.