Clinical Efficacy of Serum ESM-1 and MCP-1 in Predicting Acute Exacer-bation of Chronic Obstructive Pulmonary Disease Complicated with Pulmo-nary Hypertension
LI hui
XIE Mei
YAN Jinfang
Abstract：Objective To analyze the clinical efficacy of serum endothelial cell specific molecule-1(ESM-1)and monocyte chemotactic protein-1(MCP-1)in predicting acute exacerbation of chronic obstructive pulmonary disease(AECOPD)complicated with pulmonary hypertension.Methods A total of 128 patients with AECOPD admitted from Janu-ary 2020 to January 2024 were included and divided into combination group(mean pulmonary artery pressure≥20 mmHg,n=48)and non-combination group(mean pulmonary artery pressure＜20 mmHg,n=80)according to whether pulmonary artery pressure was combined.Serum ESM-1 and MCP-1 levels were detected in all patients after admission.General data and changes in serum ESM-1 and MCP-1 levels were compared between the two groups.The predictive value of serum ESM-1 and MCP-1 levels on AECOPD complicated with pulmonary hypertension was analyzed by receiver operating characteristic(ROC)curve,and the influencing factors of AECOPD complicated with pulmonary hypertension were analyzed by multivariate Logistic regression.Results The levels of serum C-reactive protein(CRP),D-dimer(D-D),fibrinogen(FIB),ESM-1 and MCP-1 in the combination group were higher than those in the non-combination group,and the forced expiratory volume in the first second/forced vital capacity(FEV1/FVC)were lower than those in the non-combination group(P＜0.01).The area under the ROC curve(AUC)of serum ESM-1 and MCP-1 to predict AECOPD complicated with pulmonary hypertension was 0.751 and 0.759,respectively,while the AUC of serum ESM-1 combined with MCP-1 in prediction was 0.888.Serum CRP,D-D,FIB,ESM-1,MCP-1 and FEV1/FVC were independent risk factors for AECOPD complicated with pulmonary hypertension(P＜0.01).Conclusion Serum ESM-1 and MCP-1 are significantly increased in patients with AECOPD,and their level changes are closely related to the occurrence of pulmonary hypertension,which are risk factors for AECOPD complicated with pulmonary hypertension,and the combination of the two has better clinical efficacy in the prediction.
Keywords：Pulmonary diseasechronic obstructiveAcute exacerbationPulmonary hypertensionEndothelial cell specific molecule-1Monocyte chemotactic protein-1C reactive proteinPredictive efficacyRisk factors
Publication Date：2024-11-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 38-42 )