Observation on the Curative Effect of Modified Chaixian Danshen Decoc-tion and Erchen Decoction Combined with Conventional Western Medicine in the Treatment of Coronary Heart Disease

HONG Yanping; LU Binghui; CHEN Bishan; LI Yan; WU Hanbiao; LAI Sha

doi:10.3969/j.issn.1002-3429.2024.18.014

Abstract：Objective To observe the effect of modified Chailang Danshen decoction and Erchen decoction combined with conventional Western medicine on coronary heart disease(CHD).Methods A total of 151 patients with CHD admitted from January to December 2023 were divided into the observation group(n=73)and the control group(n=78)according to different treatment methods.The control group was treated with conventional Western medicine,and the observation group was treated with modified Chailang Danshen decoction combined with Erchen decoction on the basis of control group.The frequen-cy and duration of angina pectoris,blood lipid indexes[total cholesterol,triglyceride,low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C)],inflammatory indexes[hypersensitive C reactive protein(hs-CRP),interleukin-6(IL-6)],myocardial enzyme indexes[creatine kinase,creatine kinase-MB isoenzyme(CK-MB),lactate dehydrogenase(LDH)]as well as traditional Chinese medicine(TCM)syndrome score and clinical efficacy were com-pared between the two groups after treatment.Results After treatment,the frequency and duration of angina pectoris in ob-servation group was less or shorter than that in control group(P<0.01).After treatment,the levels of total cholesterol,tri-glyceride and LDL-C in observation group were lower than those in control group,while the levels of HDL-C were higher than those in control group(P<0.05).After treatment,the levels of hs-CRP,IL-6,creatine kinase,CK-MB and LDH in obser-vation group were lower than those in control group(P<0.01).The TCM syndrome score of the observation group was lower than that of the control group,while the total effective rate of TCM syndrome[94.52％(69/73)]was higher than that of the control group[83.33％(65/78)],and the total clinical effective rate of Western medicine[90.41％(66/73)]was higher than that of the control group[82.05％(64/78)],suggesting significant differences(P<0.05,P<0.01).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Chailuo Danshen decoction and Erchen decoction combined with conventional Western medicine can effectively relieve the frequency and duration of angina pectoris in patients with CHD,regulate blood lipids,reduce inflammatory reactions,relieve TCM syn-dromes,improve clinical efficacy,and have high safety.