Analysis of the Prognostic Value of Naples Prognostic Score for Young Pa-tients with Lung Adenocarcinoma
LIANG Jinlong
PENG Lili
WANG Tingting
KANG Xiyun
ZHANG Hongzhen
Abstract：Objective To evaluate the prognostic value of Naples prognostic score(NPS)in young patients with lung adenocarcinoma.Methods The clinical data of 110 young patients with lung adenocarcinoma admitted from November 2017 to December 2022 were retrospectively analyzed.According to NPS,they were divided into low-risk group(0 point,n=27),moderate-risk group(1-2 points,n=58)and high-risk group(3-4 points,n=25).The clinical data of the three groups were compared.Kaplan-Meier and Cox regression analyses were used to evaluate the effect of NPS on prognosis.Results There were significant differences in the proportion of patients with TNM stage,lactate dehydrogenase,SII,carcinoembryonic antigen level,surgery,chemotherapy and targeted therapy among the three groups(P<0.05,P<0.01).There were no significant differences in age,sex,smoking history,marital status,body mass index,platelet/lymphocyte ratio and neuron-specific eno-lase(P>0.05).Kaplan-Meier survival analysis curve showed that the overall survival and progression-free survival of high-risk group were significantly shorter than those of low-risk and moderate-risk groups(P<0.01).TNM stage,surgery,chemo-therapy and NPS staging were independent factors affecting the OS of young lung adenocarcinoma patients(P<0.05,P<0.01).Conclusion NPS has good prognostic value in young patients with lung adenocarcinoma.
Keywords：Lung neoplasmsAdenocarcinomaNaples prognostic scoreLactate dehydrogenaseNeoplasm stagingPrognosisYoung adults
Publication Date：2024-11-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 37-43 )