Comparative Study on the Effective Components of Zhenqi Fuzheng Cap-sules,Its Traditional Chinese Medicine Formula Granules,and Traditional Decoction Tablets
WANG Yongfu
LI Yanxun
ZHANG Meng
DU Xiaona
LI Ting
Abstract：Objective To compare the differences in effective components between Zhenqi Fuzheng capsules(Ligus-trum lucidum,Astragalus)and its traditional Chinese medicine(TCM)formula granules and traditional decoction tablets.Methods Quantitative analysis was performed by high performance liquid chromatography(HPLC)to compare the content differences of the main active components(calycoisoflavone glucoside,ligustrin and astragaloside)of Zhenqi Fuzheng cap-sule,its decoction tablets of corresponding proportion and weight,and formula granules of the corresponding proportion and weight,and conduct comparative analysis according to the drug fingerprint.The peak status(peak type,peak quantity and common peak content)was compared,and the consistency of active ingredients in Zhenqi Fuzheng capsule,TCM formula granules and traditional decoction tablets was analyzed from the perspective of chemical composition.Results In Zhenqi Fuzheng capsules,the linear relationship of ligustrine,glucoside and astragaloside was good in their respective ranges(r=0.999 8,0.999 6,0.999 7).Repeatability test and stability test showed that the components of the three formulations had good repeatability and were stable within 24 h.The recovery test showed that HPLC had good accuracy in detecting the compo-nents of the three formulations of the test samples.The contents of glucoside,ligustrine and astragaloside were(5.384±0.858),(25.849±3.142)and(36.065±3.026)μg/mL,respectively,in Zhenqi Fuzheng capsule,(5.825±0.965),(25.463±3.075)and(35.618±2.847)μg/mL,respectively,in TCM formula granules,and(5.564±0.958),(25.974±2.986),(35.459±2.468)μg/mL,respectively,in traditional decoction tablets.There was no difference in the content of the above active ingredients among the three dosage forms(P＞0.05).Conclusion The main active ingredients of Zhenqi Fuzheng capsule and its TCM formula granules and traditional decoction tablets are identical,and the content had no difference,which provides the basis for Zhenqi Fuzheng capsule and TCM formula granules to replace traditional decoction tab-lets in clinical practice.
Keywords：Zhenqi Fuzheng capsuleTCM decoction tabletsChinese medicine formula granulesHigh performance liquid chromatographyFructus ligustri lucidiAstragalus membranaceusActive ingredient
Publication Date：2024-10-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 73-79 )