Exploration of Cause of Clinical Misdiagnosis of Endometrial Carcinoma Originating From Uterine Horn

CUI Xiaodong; LIU Junyan; GENG Lili; CUI Jingjing

doi:10.3969/j.issn.1002-3429.2024.16.005

Abstract：Objective To investigate the causes of misdiagnosis of endometrial carcinoma(EC)originating from uterine horn as uterine myomatosis and the preventive measures to reduce the misdiagnosis rate.Methods The clinical data of one patient with EC originating from uterine horn misdiagnosed as uterine myomatosis in March 2022 were retrospectively an-alyzed.Results The patient presented with menopausal for 3 years and lower left abdominal pain for 6 months,Color ultra-sound indicated cystic space occupying lesions(myomatosis?)in the left uterine horn.Cancer antigen 125 and carcinoembry-onic antigen normal.Endometrioid adenocarcinoma was considered by pathological examination of uterine curettage.Postoper-ative pathology showed that endometrioid adenocarcinoma in the left uterine corner was gradeⅢwith partial spindle cell differ-entiation,and combined with immunohistochemical results,stageⅢendometrioid adenocarcinoma was diagnosed.Misdiagno-sis lasted 6 d,and the patient underwent surgery.After surgical resection,the patient was treated with Paclitaxel combined with Carboplatin chemotherapy for 2 courses.The patient's general condition was good,no recurrence or metastasis was ob-served,and the follow-up was still under way.Conclusion The clinical symptoms and imaging findings of EC originating from the uterine horn are not typical,and it is more likely to be misdiagnosed as uterine myomatosis in the early stage.The possibility of multiple diseases should be considered for menopausal patients with space occupying lesions in the uterine horn,and combining the patient's medical history(including present history,past history),laboratory examination,imaging exami-nation and pathological examination can help reduce the misdiagnosis rate.