Progress in Optimizing Antibiotic Treatment Strategies for Early Sepsis
WU Di
LIU Shanshou
WANG Qianmei
LI Junjie
Abstract：Sepsis is a host response disorder caused by infection that leads to life-threatening organ dysfunction with a high fatality rate.The key to sepsis treatment is the rational use of antibiotics,including timeliness,precision and individual-ized treatment.In this study,domestic and foreign literature on antibiotic antibacterial spectrum and treatment timing,com-mon pathogens and drug resistance in different infection sites,antibiotic treatment plans and adverse reactions was systemati-cally reviewed,so as to improve the accuracy of early antibiotic selection by clinicians:Based on the epidemiology and phar-macokinetic characteristics of pathogenic bacteria,antibiotics were selected reasonably,combined with pharmacodynamics and pharmacokinetic characteristics to optimize the early antibiotic treatment strategy for sepsis,and improve the prognosis of pa-tients.
Keywords：SepsisAnti-bacterial agentsAntimicrobial SpectrumMicrobial sensitivity testsDrug resistancePharmacokineticsPharmacodynamicsReview
Publication Date：2024-09-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 95-100 )