Correlation between Carotid Body Chemoreceptor Sensitivity and Blood Pressure Control in Obese Hypertensive Patients

JIANG Xiujuan; XU Yan; WEI Zhenglin; HOU Juncheng

doi:10.3969/j.issn.1002-3429.2024.15.012

Abstract：Objective To investigate the correlation between carotid body chemoreceptor sensitivity(CBRS)and blood pressure control in obese hypertensive patients.Methods A total of 202 obese hypertensive patients admitted from Jan-uary 2022 to December 2023 were selected as the observation group,and another 101 obese patients with normal blood pres-sure during the same period were selected as the control group.Another 101 healthy volunteers during the same period served as the normal group.The CBRS,body mass index(BMI),and blood pressure were compared among the three groups.The observation group was given relevant treatment for 3 months according to the guidelines,and divided into a well-controlled sub-group(n=148)and an poorly-controlled subgroup(n=54)based on blood pressure control.The clinical characteristics and CBRS of the two subgroups were compared,and the correlation between CBRS and BMI,systolic blood pressure(SBP),dias-tolic blood pressure(DBP)was analyzed to evaluate the predictive value of CBRS,BMI,SBP,and DBP for blood pressure control and the influence of CBRS on blood pressure control.Results The CBRS of the observation group was lower than that of the control group and the normal group,and lower in the control group than in the normal group(P＜0.05).The BMI of the observation group and the control group was higher than that of the normal group,and SBP and DBP of the observation group were higher than those of the control group and the normal group(P＜0.05).BMI,SBP and DBP of the poorly-controlled subgroup were higher than those of the well-controlled subgroup,and the CBRS was lower than that of the well-controlled subgroup(P＜0.05,P＜0.01).CBRS was negatively correlated with BMI,SBP and DBP(r=-0.672,-0.710,-0.695,P＜0.05).The area under the curve of CBRS,BMI,SBP and DBP for the combined prediction of blood pressure control was greater than that of each indicator alone(P＜0.05).The CBRS was categorized into low and high values using the optimal cutoff value as a boundary,and the risk of poor blood pressure control in obese hypertensive patients with a low CBRS was 7.143 times higher than that in obese hypertensive patients with a high CBRS.Conclusion CBRS in obese hypertensive patients is strongly associated with BMI,SBP,DBP,and risk of poor blood pressure control,and can be used as an important predictor of blood pressure control.