Effect of Yiqi Pingji Granule Combined with Metoprolol Tartrate on Car-diac Function and Vascular Endothelial Function in Patients with Ventricu-lar Premature Beat of Qi-yin Deficiency Syndrome
JIA Yuzhen
JIAO Xiaomin
YU Hai
LI Jiayun
Abstract：Objective To investigate the effects of Yiqi Pingji granule combined with Metoprolol Tartrate on cardiac function and vascular endothelial function in patients with ventricular premature beat of Qi-yin deficiency syndrome.Methods From January 2019 to December 2020,100 patients with ventricular premature beat of Qi-yin deficiency syndrome were se-lected and divided into two groups using random number table method.The control group was treated with Metoprolol Tartrate,and on this basis the observation group was treated with Yiqi Pingji granule.The two groups were treated with 1 month as one course of treatment,and the therapeutic effect was compared after two consecutive courses of treatment.TCM syndrome scores,24 h holter electrocardiogram indexes,left heart function indexes and vascular endothelial related factors were com-pared between the two groups before treatment,after 1 course of treatment and 2 courses of treatment,and the clinical efficacy and treatment safety of the two groups were analyzed.Results The total effective rate of observation group was 92.00%,which was higher than that of control group(76.00%)(P＜0.05).After 1 course of treatment and 2 courses of treatment,the TCM syndrome score of the observation group was lower than that of the control group(P＜0.01).After 1 course of treat-ment and 2 courses of treatment,the frequency of ventricular premature beats in observation group was less than that in control group,the standard deviation of NN interval and the mean standard deviation of RR interval were higher than those in control group(P＜0.01).After 2 courses of treatment,left ventricular end-systolic diameter and left ventricular end-diastolic diame-ter in observation group were lower than those in control group,while left ventricular ejection fraction was higher than those in control group(P＜0.01).After one course of treatment and two courses of treatment,the levels of thromboxane B2 and endo-thelin-1 in the observation group were lower than those in the control group,while nitric oxide was higher than that in the con-trol group(P＜0.01).There was no significant difference in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusion Yiqi Pingji Granule combined with Metoprolol Tartrate can improve the clinical symptoms and signs of patients with ventricular premature beat of Qi-yin deficiency syndrome,promote the recovery of heart function,and regulate the expression of thromboxane B2,endothelin-1,nitric oxide and other vascular endotheles-related factors,with good efficacy and treatment safety.
Keywords：Ventricular premature beatQi-yin deficiencyYiqi Pingji granuleMetoprolol artrateTCM syndrome scoreLeft ventricular end-systolic diameterThromboxane B2Endothelin-1
Publication Date：2024-09-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 84-89 )