Effects of Remazolam Combined with Different Doses of Propofol on Seda-tion and Adverse Reactions in Patients Undergoing Total Laparoscopic Hys-terectomy
YANG Yong
LI Xiangcheng
WANG Kun
TAO Hemei
GE Jianling
Abstract：Objective To investigate the effects of Remazolam combined with different doses of Propofol on sedation and adverse reactions in patients induced by anesthesia during total laparoscopic hysterectomy(TLH).Methods A total of 96 patients undergoing TLH from April 2021 to August 2023 were selected and divided into group A(n=48)and group B(n=48)according to random number table method.All patients were induced with Remazolam combined with Propofol.The dosage of Propofol was 0.5 mg/kg in group A and 1.0 mg/kg in group B.Perioperative indexes,anesthesia induction,hemo-dynamic indexes at the beginning of anesthesia induction(T0),immediately before mechanical ventilation(T1)and at 3 min after mechanical ventilation(T2),and the occurrence of intraoperative and postoperative adverse reactions were compared be-tween the two groups.Results There were no significant differences in the duration of operation,intraoperative blood loss and fluid replenishment between the two groups(P＞0.05).The time of anesthesia induction in group B was shorter than that in group A,and rescue with Propofol in group B was less than that in group A(P＜0.05,P＜0.01).Heart rate(HR),mean arterial pressure(MAP)and bispectral index(BIS)of the two groups showed a decreasing trend at T0-T2(P＜0.05),but there were no significant differences in HR,MAP and BIS values between the two groups at the same time point(P＞0.05).The totaladversereactionrateofgroup B(60.42%)washigherthanthatofgroup A(25.00%)(P＜0.01).Con-clusion Remazolam combined with low-dose Propofol can play a better sedative and hemodynamic role in TLH,and the seda-tive effect is better when the dosage of Propofol is 1.0 mg/kg,but the incidence of adverse reactions is higher.
Keywords：Total laparoscopic hysterectomyAnesthesiaRemazolamPropofolHeart rateMean arterial pressureBispectral indexDrug toxicity
Publication Date：2024-09-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 70-73 )