Correlation between D-dimer,NLR,PLR,CRP,FEV1/FVC Levels and the Severity of Chronic Obstructive Pulmonary Disease
ZHENG Xiaohui
LI Yanmei
Abstract：Objective To investigate the correlation between D-dimer(DD),neutrophil to lymphocyte ratio(NLR),platelet/lymphocyte ratio(PLR),C reactive protein(CRP),forced expiratory volume in the first second(FEV1)/forced vital capacity(FVC)and the severity of chronic obstructive pulmonary disease(COPD).Methods A total of 113 pa-tients with COPD admitted from August 2019 to October 2021 were selected as COPD group,and then according to the per-centage of forced expiratory volume in the first second in the expected value divided into moderate and mild group and severe group.Another 50 healthy people who underwent physical examination during the same period were selected as the healthy control group.The serum DD,NLR,PLR and CRP levels of all the included researchers were examined,and the levels of pe-ripheral blood indexes in COPD group and healthy control group were observed and compared.The levels of peripheral blood indexes and pulmonary function FEV1/FVC in COPD patients with different disease severity were compared.Pearson correla-tion coefficient was used to analyze the correlation between DD,NLR,PLR,CRP,FEV1/FVC levels and the severity of COPD patients.Multivariate Logistic regression was used to analyze the risk factors of exacerbation of COPD.Results The levels of DD PLR,CRP and NLR in COPD group were significantly higher than those in healthy control group(P＜0.05).The levels of DD,PLR,CRP and NLR in severe group were significantly higher than those in moderate and mild group,and the levels of FEV1/FVC were significantly lower than those in moderate and mild group(P＜0.05).DD,PLR,CRP and NLR were positively correlated with the severity of COPD patients(r=0.561,0.782,0.773,0.857,P＜0.01),while FEV1/FVC levels were negatively correlated with the severity of COPD patients(r=-0.983,P＜0.01).DD was positively correlated with PLR(r=0.872,P＜0.05),and with CRP(r=0.714,P＜0.05).PLR was positively correlated with CRP(r=0.798,P＜0.05),and NLR was positively correlated with CRP(r=0.857,P＜0.05).The higher levels of DD,PLR,CRP,NLR and the lower levels of inFEV1/FVC levels were independent risk factors for the exacerbation of COPD pa-tients(P＜0.01).Conclusion The levels of DD,PLR,CRP,NLR,and FEV1/FVC are closely related to the severity of COPD,which can be used as a routine predictor to reflect the change of disease condition.
Keywords：Chronic obstructive pulmonary diseaseD-dimerNeutrophil to lymphocyte ratioPlatelet/lymphocyte ratioC reactive proteinForced expiratory volume in the first secondForced vital capacityCorrelation analysis
Publication Date：2024-09-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 48-54 )