Effects of Modified Bazhen Decoction on Clinical Efficacy and Immune In-dexes of Patients Undergoing Extended Endoscopic Resection for Nasopha-ryngeal Carcinoma and Postoperative Radiotherapy
LIU Shuhong
PENG Jun
TANG Libin
LIU Chunqiu
ZHANG Lijie
Abstract：Objective To observe the effects of modified Bazhen decoction on clinical efficacy and immune indexes of patients undergoing extended endoscopic resection for nasopharyngeal carcinoma(NPC)and postoperative radiotherapy.Methods In total,94 NPC patients who underwent extended endoscopic resection for NPC from May 2022 to January 2024 were selected as the research subjects,and were divided into control group(n=47)and observation group(n=47)by ran-dom number table method.All patients underwent postoperative radiotherapy.The control group was given conventional nutri-tional intervention after radiotherapy and treatment of adverse reactions.The observation group was given modified Bazhen de-coction on the basis of control group.The clinical efficacy,salivary function,pain degree,immune function and quality of life of the two groups were compared,and the adverse reactions were observed.Results The objective remission rate in the ob-servation group was82.89%(39/47),which was higher than that in the control group[63.83%(30/47)](P＜0.05).After treatment,the salivary gland secretion index,nasopharyngeal cancer quality of life scale score,CD3+and CD4+/CD8+levels in the observation group were higher than those in the control group(P＜0.05),while the visual ana-logue scale pain score and CD8+levels in the observation group were lower than those in the control group(P＜0.05).The incidence of platelet/leukopenia and oral mucositis in the observation group was lower than that in the control group(P＜0.05).Conclusion Modified Bazhen decoction can improve the radiotherapy effect of NPC patients undergoing extended en-doscopic resection for NPC and postoperative radiotherapy,relieve pain,improve salivary secretion function,regulate immune function,and reduce adverse reactions,thus playing a role in enhancing efficacy and reducing toxicity.
Keywords：Nasopharyngeal carcinomaExtended resection for nasopharyngeal carcinomaNasal endoscopeRadia-tion therapyBazhen decoctionImmune functionPainAdverse reactions
Publication Date：2024-08-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 91-94,100 )