Effects of Metformin Combined with Agomelatine on the Clinical Efficacy and Ovarian Function of Perimenopausal Female Patients with Type 2 Dia-betes Mellitus and Comorbid Depression
ZHAO Bingying
LI Na
WANG Yan
WANG Jingxian
DU Juan
Abstract：Objective To investigate the effect of Metformin combined with Agomelatine on clinical efficacy and ovar-ian function of perimenopausal patients with type 2 diabetes mellitus(T2DM)and comorbid depression.Methods A total of 200 perimenopausal female patients with T2DM and comorbid depression were selected from January 2017 to December 2019.They were divided into control group and research group by random number table method,with 100 patients in each group.Both groups were treated with Metformin,the control group was supplemented with Venlafaxine and the research group was supplemented with Agomelatine.The changes in sleep status,depression score,ovarian function,quality of life score,blood glucose level and safety of the two groups were compared before and after treatment.Results After treatment,the scores of Pittsburgh sleep quality index,fasting blood glucose and 2 h postprandial blood glucose in the research group were lower than those before treatment and those in the control group(P＜0.05).Compared with the control group,the Hamilton Depression Scale scores of the research group were lower at 7,21 and 42 d after treatment(P＜0.05).After treatment,estradiol level and quality of life comprehensive assessment questionnaire scores in the research group were higher than those before treatment and in the control group(P＜0.05).There were no differences in luteinizing hormone and follicle stimulating hormone levels between the two groups(P＞0.05).The total incidence of adverse reactions in the research group was lower than that in the control group(P＜0.05).Conclusion The use of Metformin combined with Agomelatine in the treatment of perimenopausal female patients with T2DM and comorbid depression can significantly alleviate depression and improve the patients'sleep sta-tus,without affecting their ovarian function,and its safety and clinical effects are excellent.
Keywords：PerimenopausalDiabetes mellitustype 2Depressive disorderAgomelatineMetforminOvarian functionSleepQuality of life
Publication Date：2024-08-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 82-86 )