Effect of Magnesium Valproate Combined with Donepezil on Mental and Behavioral State,Serum Neurotransmitters and Cytokines in Patients with Alzheimer's Disease
QIAO Yu
ZHANG Yang
LEI Biao
YU Pengbo
WANG Xiaofeng
YANG Xiaoliang
Abstract：Objective To explore the effects of Magnesium Valproate combined with Donepezil on serum lipoprotein phospholipase A2(Lp-PLA2),ceruloplasmin(CER)and brain-derived neurotrophic factor(BDNF)levels and mental and behavioral state of patients with Alzheimer's disease.Methods A total of 104 patients with Alzheimer's disease treated from August 2020 to August 2023 were randomly divided into combination group(n=52)and monotherapy group(n=52).The monotherapy group was treated with Donepezil Hydrochloride tablets,and the combination group was treated with Magnesium Valproate tablets on the basis of monotherapy group.Both groups were treated for 16 weeks.The scores of mental and behav-ioral status,the levels of serum neurotransmitters and cytokines,and the occurrence of adverse reactions during treatment were observed before and at 16 weeks after treatment.Results At 16 weeks after treatment,the scores of abbreviated Montreal Cognitive Assessment Scale and serum levels of γ-aminobutyric acid,glutamic acid,5-hydroxytryptamine,CER and BDNF in combination group and monotherapy group were higher than those before treatment,and higher in the combination group than in the monotherapy group(P＜0.05).At 16 weeks after treatment,the scores of Alzheimer's disease Assessment Scale-Cogni-tive Subscale,Blessed Roth Behavioral Scale,Neuropsychiatric symptom questionnaire and serum Lp-PLA2 levels in combina-tion group and monotherapy group were lower than those before treatment,and lower in the combination group than in the monotherapy group(P＜0.05).During treatment,the total incidence of adverse reactions in combination group and mono-therapy group was 21.15%(11/52)and 23.08%(12/52),respectively,and there was no significant difference between the two groups(P＞0.05).Conclusion Magnesium Valproate combined with Donepezil could effectively improve the levels of serum CER,BDNF and neurotransmitter in patients with Alzheimer's disease,and reduce the level of serum Lp-PLA2,thereby reducing the injury of nerve cells,promoting the transmission of neuronal information,and effectively improving their mental and behavioral state with good safety.
Keywords：Alzheimer's diseaseMagnesium valproateDonepezilCognitionLipoprotein phospholipase A2Ceru-loplasminBrain-derived neurotrophic factorγ-aminobutyric acid
Publication Date：2024-08-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 77-81 )