Effects of High-flux Low-calcium Hemodialysis on Serum MCP-1,β2-MG and Urea Clearance Index in Elderly Patients with Uremia
KONG Ziang
GE Jun
YUAN Juan
Abstract：Objective To analyze the efficacy of high-flux low-calcium hemodialysis in the treatment of elderly pa-tients with uremia.Methods In total,380 elderly patients with uremia treated from December 2017 to June 2022 were se-lected and divided into control group and observation group by random number table method,with 190 patients in each group.The control group received low-flux hemodialysis,and the observation group received high-flux low-calcium hemodialysis.The renal function[serum creatinine(Scr),blood urea nitrogen(BUN),β2-microglobulin(β2-MG)],monocyte chemoattrac-tant protein-1(MCP-1),serum calcium and phosphorus metabolism indexes and urea clearance index(Kt/V)of the two groups were compared.Results The total effective rate of observation group was 92.63%,which was higher than that of con-trol group(73.68%)(P＜0.05).After treatment,the levels of Scr,BUN,β2-MG,MCP-1,serum calcium and serum phosphorus in observation group were decreased compared with those in control group(P＜0.05).Kt/V in the observation group was increased as compared with that in the control group(P＜0.05).There was no significant difference in the inci-dence of adverse reactions between the two groups(P＞0.05).Conclusion High-flux low-calcium hemodialysis is an ideal treatment option for elderly patients with uremia,which can obviously reduce serum MCP-1 level and increase Kt/V,and has high clinical application value.
Keywords：UremiaHigh-flux hemodialysisLow-calcium dialysateLow-flux hemodialysisElderlyMonocyte chemoattractant protein-1β2-microglobulinUrea nitrogen
Publication Date：2024-08-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 62-65,70 )