Relationship between Peripheral Blood TIMP-1,TIMP-2,TSAT Level and Clinical Outcomes in Patients with Peritoneal Dialysis-associated Peritonitis
LI Yaqi
GUO Baozhu
CHENG Jinxiu
JIN Yujie
Abstract：Objective To analyze the levels of tissue inhibitor of metalloproteinase-1(TIMP-1),tissue inhibitor of metalloproteinase-2(TIMP-2)and transferrin saturation(TSAT)in peripheral blood of peritoneal dialysis-associated peritoni-tis(PDAP)patients and their relationship with clinical outcomes.Methods A total of 100 patients with PDAP admitted from August 2021 to February 2023 were selected and divided into cure group(n=68)and worsening group(n=32)according to their clinical outcomes within 1 year after removal of peritoneal dialysis tube.The clinical data and peripheral blood TIMP-1,TIMP-2 and TSAT levels were compared between the two groups.Multivariate Logistic regression analysis was used to analyze the independent risk factors for the deterioration of PDAP in those patients.The predictive value of TIMP-1,TIMP-2 and TSAT for clinical outcome of patients was analyzed by receiver operating characteristic(ROC)curve.Results The dialysis age in the worsening group was higher than that in the cure group,the proportion of patients with history of peritonitis was higher than that in the cure group,and the TIMP-1,TIMP-2 and TSAT levels were lower than those in the cure group(P＜0.01).Low levels of TIMP-1,TIMP-2 and TSAT were independent risk factors for deterioration of PDAP in those patients(P＜0.05).ROC curve analysis showed that the area under the ROC curve(AUC)of TIMP-1,TIMP-2 and TSAT in predic-ting the clinical outcome of PDAP patients were 0.759,0.702 and 0.739,respectively,and that the AUC of the combined detection of the above indicators was 0.813,which had better predictive value(P＜0.05).Conclusion TIMP-1,TIMP-2 and TSAT levels were reduced in PDAP patients with worsening disease,and the three factors detected alone and in combina-tion had high predictive value for clinical outcomes of patients.
Keywords：Peritoneal dialysisPeritonitisTissue inhibitor of metalloproteinase-1Tissue inhibitor of metalloprotei-nase-2Transferrin saturationClinical outcomeRisk factorsReceiver operating characteristic curve
Publication Date：2024-08-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 40-44 )