Value of ADA,VEGF and Serum CEA and CA125 in Differentiating Be-nign and Malignant Pleural Effusion
ZHANG Tingxiu
HU Sheng
MA Lijie
XIAO Zhenliang
Abstract：Objective To study the value of adenosine deaminase(ADA),vascular endothelial growth factor(VEGF)combined with serum carcinoembryonic antigen(CEA)and carbohydrate antigen 125(CA125)in differentiating be-nign and malignant pleural effusion.Methods A retrospective study was conducted on 188 patients with pleural effusion hos-pitalized from January 2022 to September 2023.According to cytology and percutaneous pleural biopsy results,they were di-vided into benign group(n=105)and malignant group(n=83)according to the nature of pleural effusion.ADA,VEGF in pleural effusion and serum CEA and CA125 levels were detected and compared between the two groups.The value of ADA,VEGF and serum CEA and CA125 in the diagnosis of malignant pleural effusion was analyzed by receiver operating characteris-tic(ROC)curve.Kappa consistency was used to analyze the accuracy of ADA,VEGF and serum CEA and CA125 in the di-agnosis of malignant pleural effusion.Results The ADA level of pleural effusion in benign group[(54.47±8.96)U/L]was higher than that in malignant group[(21.49±5.37)U/L],while the levels of VEGF and serum CEA and CA125 in pleural effusion[(213.46±35.27)ng/mL,(1.95±0.52)μg/mL,(324.59±9.26)U/mL]were lower than those in malignant group[(409.81±46.63)ng/mL,(21.39±3.54)μg/mL,(408.73±98.14)U/mL](P＜0.05).ROC curve analysis confirmed that ADA,VEGF,serum CEA and CA125 had certain value in the diagnosis of malignant pleural effusion,and the areas under the curve(AUC)of the above indicators were0.880,0.871,0.892 and 0.796,respectively(all P＜0.05).According to Kappa consistency analysis,the sensitivity of ADA,VEGF,serum CEA and CA125 in the diagnosis of malignant pleural effusion was 0.943,the specificity was 0.867,the accuracy was 0.910,and Kappa=0.815.Conclusion ADA,VEGF in pleural effusion and serum CEA and CA125 can be used in the differentiation of malignant pleu-ral effusion.The combined detection of ADA,VEGF and CA125 can be used in the diagnosis of malignant pleural effusion.
Keywords：Pleural effusionBenign and malignantAdenosine deaminaseVascular endothelial growth factorCar-cinoembryonic antigenCarbohydrate antigen 125DiagnosisdifferentialReceiver operating characteristic curve
Publication Date：2024-08-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 35-39 )