Clinical Significance of Color Doppler Ultrasound and miRNAs Detection in Patients with Chronic Heart Failure before and after Treatment with Com-bined Traditional Chinese Medicine and Western Medicine
LI Yunfeng
ZHANG Xiaomei
WU Haiyan
MENG Yuanhua
HUA Jinfeng
YANG Xiaojing
Abstract：Objective To analyze the clinical significance of color Doppler ultrasound parameters and microRNAs(miRNAs)detection in patients with chronic heart failure(CHF)before and after treatment with combined traditional Chinese medicine(TCM)and Western medicine.Methods A total of 162 patients with CHF admitted from January 2020 to April 2023 were selected as the research subjects and divided into cardiac function Ⅱ group(n=47),cardiac function Ⅲ group(n=75),and cardiac function Ⅳ group(n=40)according to the New York Heart Association cardiac function classifica-tion.The color Doppler ultrasound parameters[left ventricular ejection fraction(LVEF),left atrial diameter(LAD)and left ventricular end diastolic diameter(LVEDd)]and the expression levels of miRNAs(miRNA-208,miRNA-130a)were com-pared before and after the treatment for CHF with different cardiac function classifications.The correlation between color Doppler ultrasound parameters,miRNAs and cardiac function classifications was analyzed,the color Doppler ultrasound pa-rameters and expression levels of miRNAs in patients with CHF with different prognosis were compared,and their prognostic value for the treatment with combined TCM and Western medicine was analyzed.Results Before and after treatment,LVEF in cardiac function Ⅱgroup was the highest followed by cardiac functionⅢgroup and cardiac functionⅣgroup,while LAD,LVEDd,and miRNA-208 and miRNA-130a expression levels were the lowest in cardiac functionⅡgroup,followed by cardiac function class Ⅲ group and cardiac function class Ⅳ group(P＜0.05).After treatment,compared with those before treat-ment,with combined TCM and Western medicine,the LVEF level in patients with CHF of different cardiac function classifica-tions was increased,while LAD,LVEDd,miRNA-208,and miRNA-130a expression levels were decreased(P＜0.05).Be-fore and after treatment,LVEF was negatively correlated with the cardiac function in patients with CHF,while LAD,LVEDd,and miRNA-208,and miRNA-130a expression were positively correlated with the cardiac function classifications(P＜0.01).Before and after treatment,the LVEF in the poor prognosis group was lower than that in the good prognosis group,while the LAD,LVEDd,and miRNA-208 and miRNA-130a expression levels were higher than those in the good prognosis group(P＜0.05).After treatment,compared with those before treatment,LVEF in patients with CHF of different prognoses was in-creased,while LAD,LVEDd,and miRNA-208 and miRNA-130a expression levels were decreased(P＜0.05).The area un-der the curve of the combined detection of color Doppler ultrasound parameters and miRNAs before and after treatment in eval-uating the prognosis of CHF patients was the largest,with the values of 0.915(95%CI:0.861,0.953)and 0.943(95%CI:0.896,0.974),respectively.Conclusion Color Doppler ultrasound parameters,miRNA-208 and miRNA-130a expression are closely related to cardiac function classifications in CHF patients before and after treatment with combined TCM and Western medicine,the combined detection of color Doppler ultrasound parameters and miRNAs has high evaluation value for the prognosis of CH.
Keywords：Chronic heart failureColor ultrasoundmiRNA-208miRNA-130aLeft ventricular ejection fractionCardiac functionPrognosisReceiver operating characteristic curve
Publication Date：2024-08-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 28-34 )