Clinical Efficacy of Non-invasive Positive Pressure Ventilation in the Treatment of Early Acute Respiratory Failure in the Prone Position
WANG Li'ao
ZHANG Lei
WANG Meiying
LI Zhengqiao
HOU Yunsheng
Abstract：Objective To explore the clinical effect of non-invasive positive pressure ventilation(NIPPV)in the prone position in patients with acute respiratory failure(ARF).Methods A total of 100 patients with ARF admitted from March 2021 to March 2024 were selected as the research subjects by convenience sampling method and divided into group A(n=50)and group B(n=50)by random number table method.Group A received NIPPV in the prone position,group B received NIPPV in the supine position.Clinical effects of different ventilation modes in patients with early ARF were analyzed.The changes in hemodynamic indexes[heart rate(HR),mean arterial pressure(MAP)],respiratory function monitoring indexes[re-spiratory rate,arterial partial pressure of oxygen(PaO2),arterial partial pressure of carbon dioxide(PaCO2),blood oxygen satu-ration(SpO2)],oxygenation index and pH value of the two groups were analyzed at 0,12 and 24 h after treatment were ana-lyzed.The therapeutic effects(endotracheal intubation rate,mortality rate and complication rate within 24 h)of the two groups were compared,and the correlation between the time from admission to NIPPV in the prone position and the total time of NIPPV was analyzed.Results In group A,HR,MAP,respiratory rate and PaCO2 all showed a decreasing trend,while PaO2,SpO2 and oxygenation index all showed an increasing trend,showing significant differences(P＜0.05,P＜0.01).There was no significant difference in pH value between the two groups at 0 h,12 h,and 24 h after admission(P＞0.05).The rate of endo-tracheal intubation,mortality and complications within 24 h after admission in group A were lower than those in group B(P＜0.05).The time from admission to NIPPV in the prone position was significantly correlated with the total duration of NIPPV(r=0.34,P＜0.01).Conclusion Early application of NIPPV in the prone position in patients with ARF can significantly improve hemodynamics,respiratory function,oxygenation and other related indexes,and the therapeutic effect is obvious.
Keywords：Respiratory insufficiencyProne positionNon-invasive positive pressure ventilationHemodynamicsArterial partial pressure of oxygenBlood oxygen saturationOxygenation index
Publication Date：2024-08-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 50-56 )