Effect of Elephant Skin Powder Combined with Anisodamine Hydrobromide in the Treatment of Ischemic Diabetic Foot

QIN Xiaoli; XU Yanrong; SHANG Hongbo

doi:10.3969/j.issn.1002-3429.2024.11.012

Abstract：Objective To analyze the effect of elephant skin powder and Anisodamine Hydrobromide in the treat-ment of ischemic diabetic foot(IDF).Methods In total,93 patients with IDF treated from August 2020 to October 2021 were selected and divided into the three groups according to different treatment methods.The observation group was treated with el-ephant skin powder combined with Anisodamine Hydrobromide,control group one was treated with external application of ele-phant skin powder,and control group two was treated with Anisodamine Hydrobromide.The clinical efficacy at 1 month after treatment,and hemodynamic indexes,inflammatory factors,quality of life scores before and after treatment and adverse reac-tions during treatment were compared between the three groups.Results After treatment,the total effective rate of observa-tion group was 96.77%(30/31),which was higher than that of control group one and control group two[74.19%(23/31),77.42%(24/31)](P<0.05).After treatment,fibrinogen,hematocrit,plasma viscosity,interleukin-6,vascular cell adhesion factor-1 and endothelin-1 were all decreased in the three groups,which were lower in observation group than in control group one and con-trol group two(P<0.05).After treatment,the scores of all dimensions of the health survey questionnaire of the three groups were increased,which were higher in the observation group than in control group one and control group two(P<0.05).The in-cidence of adverse reactions during treatment in observation group was lower than that in control group one and control group two(P<0.05).Conclusion The combination of elephant skin powder and Anisodamine Hydrobromide in the treatment of IDF patients is effective,which can accelerate wound healing,control the occurrence of adverse reactions,regulate the hemodynac in dexes and inflammatory reactions,and effectively improve the quality of life.