Pharmacogenomic Study of Primary Hypertensive Patients Taking Nifedip-ine
QIN Li
LU Feng
CHEN Haibi
LI Hua
ZHANG Zhiyong
MU Huaibin
LI Si
ZHENG Wencheng
Abstract：Objective To analyze the distribution of drug-related gene polymorphism in primary hypertensive patients taking Nifedipine based on pharmacogenomics technology,and to evaluate the application value of gene-directed use of Nife-dipine.Methods A total of 485 patients with primary hypertension who took Nifedipine from October 2021 to October 2023 were selected as research subjects,to analyze Nifedipine drug-related genes,further analyze the genotype distribution of each gene polymorphism site,and compare the genotype distribution of each gene polymorphism site in patients with different thera-peutic effects and with or without lower limb edema.Univariate and multivariate Logistic regression analyses were performed to analyze the relationship of gene polymorphic loci with therapeutic effect and lower limb edema.Results Cytochrome P450(CYP)3A5∗3 A6986G,urea-transporter glycoprotein A2 antibody(SLC14A2)rs1123617,SLC14A2 rs3745009,CYP3A4 rs2242480,adrenergic α1 A receptor(ADRA1A)rs1048101,adrenergic β1 receptor(ADRB1)c.1165,adrenergic β2 recep-tor(ADRB2)rs1042713 and angiotensin converting enzyme(ACE)rs4646994 polymorphisms were consistent with the Hardy-weinberg equilibrium law,suggesting that the samples were representative.The genotypes of CYP3A5∗3 A6986,CYP3A4 rs2242480,ADRB1 c.1165,ADRB2 rs1042713 and ACE rs4646994 in patients with different therapeutic effects and with or without lower limb edema were statistically significant(P＜0.05,P＜0.01),while there were no significant difference in genotype comparison between SLC14A2 rs1123617,SLC14A2 rs3745009,and ADRA1A rs1048101 loci(P＞0.05).Univariate and multivariate Logistic regression analyses showed that CYP3A5∗3 A6986 G＞A,CYP3A4 rs2242480 C＞T,ADRB1 c.1165 C＞G,ADRB2 rs1042713 G＞A,and ACE rs4646994 I＞D were significantly correlated with the effi-cacy and lower limb edema of primary hypertensive patients taking Nifedipine(P＜0.01).Conclusion Drug-related gene polymorphism in primary hypertensive patients taking Nifedipine is closely related to efficacy and lower limb edema,which can provide reference for clinicians to make personalized treatment plan.
Keywords：PharmacogenomicsHigh blood pressureNifedipineGene polymorphismGene lociCorrelation
Publication Date：2024-07-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：8( 55-62 )