Effects of Gujingcao Modified Formula on Blood Pressure,Renin Activity,Angiotensin Ⅱ and Aldosterone in Patients with Hypertension Induced by Syndrome of Liver Depression Transforming into Fire

ZHAO Cunfang; WANG Qiang; LI Huizhou; SHI Jiasen; WANG Chunliang; BI Junfang; CUI Xi-aohui; WAN Xinmiao; SHEN Xuena

doi:10.3969/j.issn.1002-3429.2024.09.017

Abstract：Objective To observe the effects of Gujingcao modified formula combined with Irbesartan tablets on blood pressure,plasma renin activity(PRA),angiotensinⅡ(AngⅡ)and aldosterone(ALD)levels in patients with hypertension induced by syndrome of liver depression transforming into fire.Methods From January 2022 to February 2023,80 patients with hypertension induced by syndrome of liver depression transforming into fire were selected and divided into two groups ac-cording to random number table method.Of them,40 patients in the control group were treated with Irbesartan tablets,and 40 patients in the observation group were treated with Gujingcao modified formula on the basis of the control group.Both groups were treated for 8 weeks.Blood pressure-related indexes,TCM syndrome scores,serum levels of PRA,AngⅡand ALD,and adverse reactions during treatment were compared between the two groups before and after treatment.Results At 8 weeks af-ter treatment,the total effective rate of observation group was92.50%(37/40),which was higher than that of control group[75.00(30/40)](P＜0.05).After treatment,daytime systolic blood pressure(SBP),daytime diastolic blood pressure(DBP),nighttime SBP,nighttime DBP,24 h SBP,24 h DBP and blood pressure load in the two groups were decreased com-pared with those before treatment,which were better in the observation group than in the control group(P＜0.05).After treatment,the scores of all TCM syndromes in the observation group decreased,while the scores of only dizziness and head-ache in the control group decreased(P＜0.05).The scores of TCM syndromes in the observation group were better than those in the control group(P＜0.05).After treatment,serum PRA in the two groups was higher than that before treatment,while AngⅡ and ALD were lower than those before treatment(P＜0.05).After treatment,PRA level in the observation group was higher than that in the control group,while AngⅡ and ALD levels were lower than those in the control group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Gujingcao modified formula combined with Irbesartan tablets can reduce blood pressure,improve clinical symptoms,and effec-tively inhibit AngⅡ and ALD levels in the treatment of hypertension induced by syndrome of liver depression transforming into fire,showing significant effect and good safety.