Effect of Nebulized Inhalation of Moxifloxacin with Non-invasive Ventilator for the Treatment of AECOPD Complicated with Pulmonary Infection

ZHANG Fan; CHEN Haitao; HU Yi; JI Hongkai

doi:10.3969/j.issn.1002-3429.2024.09.014

Abstract：Objective To investigate the effect of nebulized inhalation of Moxifloxacin solution combined with non-invasive ventilator in the treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD)complicated with pulmonary infection.Methods A total of 120 patients with AECOPD complicated with pulmonary infection from January 2020 to January 2023 were selected and divided into observation group(n=60)and control group(n=60)by random num-ber table method.Both groups were given conventional treatment.On this basis,the control group was given non-invasive ventilator,and the observation group was given nebulized inhalation of Moxifloxacin solution combined with non-invasive venti-lator.Both groups were treated for 2 weeks.The clinical efficacy,auxiliary respiratory muscle score,acute physiological and chronic health status Ⅱ(APACHEⅡ)score,blood gas analysis[partial pressure of carbon dioxide(PaCO2),arterial oxy-gen partial pressure(PaO2),arterial oxygen saturation(SaO2)],serum inflammatory factor[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),C response protein(CRP)],and mRNA expression related to NOD-like receptor protein 3(NLRP3)/Caspase-1/interleukin-1β(IL-1β)inflammatory and immune signaling pathways before treatment,and at 3 d and 7 d after treatment were compared between the two groups.Results The total effective rate of observation group[96.67%(58/60)]was higher than that of control group[85.00%(51/60)](P＜0.05).At 3 and7 d after treatment,the scores of auxiliary respiratory muscle,APACHEⅡ scores,levels of TNF-α,IL-6,CRP,NLRP3,Caspase-1 and IL-1β mRNA in ob-servation group were lower than those in control group(P＜0.05).At 3 and 7 d after treatment,PaO2 and SaO2 in the obser-vation group were higher than those in the control group,while PaCO2 was lower than that in the control group(P＜0.05).Conclusion Nebulized inhalation of Moxifloxacin solution combined with non-invasive ventilator can improve blood gas inde-xes,reduce serum inflammatory factors,and improve the health status of patients with AECOPD complicated with pulmonary infection,and the therapeutic effect is significant,which may be related to the regulation of NLRP3/Caspase-1/IL-1β inflam-matory and immune signaling pathway.